ethyl 3-methylH-imidazo[1,2-a]pyridine-2-carboxylate synthesis
- Product Name:ethyl 3-methylH-imidazo[1,2-a]pyridine-2-carboxylate
- CAS Number:1038828-20-4
- Molecular formula:C11H12N2O2
- Molecular Weight:204.23
Yield:1038828-20-4 74%
Reaction Conditions:
with 1-hydrogeno-3-butylimidazolium tetrafluoroborate at 20; for 0.833333 h;Green chemistry;Reagent/catalyst;
Steps:
A mixtureof 2-aminopyridine 1a (1 mmol) and β-nitroacrylate 2a (1 mmol) in 5 mL ionic liquid[Hbim]BF4 was stirred at roomtemperature for stipulated time (Table 1). The progress of the reaction was monitored by TLC. After the completionof the reaction, the reaction mixture was extracted with ether (3x15 mL). The combined organic layers were washedwith brine solution, and dried over Na2SO4. TheNa2SO4 was filtered off and the solventwas removed under vacuum. The residue obtained was then purifiedby silica gel column chromatography (100-200 mesh) using ethyl acetate: hexane(5:95 to 20:80) as eluent to get corresponding products
References:
Babu, B. Madhu;Kumar, G. Santosh;Thakur, Pramod B.;Bangade, Vikas M.;Meshram [Tetrahedron Letters,2014,vol. 55,# 24,p. 3473 - 3477] Location in patent:supporting information
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![Imidazo[1,2-a]pyridine-2-carboxylic acid, 3-methyl-, methyl ester](/CAS/20210305/GIF/668276-24-2.gif)
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