ChemicalBook CAS DataBase List 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone

2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone synthesis

6synthesis methods

Product Name:2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone
CAS Number:106797-53-9
Molecular formula:C12H16O4
Molecular Weight:224.25

1-Propanone, 1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-

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2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone

106797-53-9
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Yield:106797-53-9 92%

Reaction Conditions:

with N-Bromosuccinimide;dimethyl sulfoxide at 60; for 24 h;Schlenk technique;

Steps:

26 Embodiment 262 - hydroxy -4 ' - (2 - hydroxy ethoxy group) -2 - methylpropiophenone preparation

Taking a 25 ml Schlenk reaction tube, adding N - bromo succimide (NBS) 18 mg (0.1mmol) as catalyst, 4' - (2 - hydroxy ethoxy group) -2 - methylpropiophenone 105 mg (0.5mmol), dimethyl sulfoxide (DMSO) 1 ml as the oxidizing agent, carbonylating and solvent, for 100 °C stirring for 24 hours. After the reaction by adding ethyl acetate 15 ml, salt water 3 ml, ethyl acetate 3 times, the combined organic phase, column chromatography separation to obtain 2 - hydroxy -4 ' - (2 - hydroxy ethoxy group) -2 - methylpropiophenone pure product 103 mg, yield 92%.

References:

CN104710256,2017,B Location in patent:Paragraph 0174-0177