4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid synthesis
- Product Name:4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid
- CAS Number:1174046-90-2
- Molecular formula:C14H12FNO4
- Molecular Weight:277.25
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Yield: 84%
Reaction Conditions:
with lithium hydroxide monohydrate in ethanol;water at 70;
Steps:
1.3 Step 3: Synthesis of 4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
The compound obtained in step 2 (1.5 g, 4.91 mmol) was dissolved in 15 mL of ethanol and 10 mL of water, and then lithium hydroxide monohydrate (0.82 g, 19.6 mmol) was added at room temperature and stirred at 70 ° C for 3 hours or more. It was. After cooling to room temperature, the solvent was concentrated under reduced pressure, and 1N hydrochloric acid aqueous solution was slowly added dropwise at 0 ° C. to maintain a pH of 2.0. The resulting solid was filtered, washed with water and dried to give the title compound (1.1 g, yield: 84%, white solid).
References:
Welmakeo Bio Co., Ltd.;Lee Hyeon-ho;Park Jun-ho;Huh Seon-cheol;Moon Jae-hui;Shin Jae-sik;Hong Seung-u;Park Yun-seon;Kim Yo-sep;Lee So-hui;Kim Hyo-jin;Park Hye-bin KR2019/106802, 2019, A Location in patent:Paragraph 0171; 0180-0183
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