ChemicalBook CAS DataBase List 2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin

2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin synthesis

3synthesis methods

Product Name:2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin
CAS Number:117977-20-5
Molecular formula:C11H16ClNO2
Molecular Weight:229.7

2-Hydroxymethyl-3-methyl-4-(3-methoxy propanoxyl)pyridine

118175-10-3
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$9.00/250mg

2-Chloromethyl-4-(3-methoxypropoxy)-3-methylpyridin

117977-20-5
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Yield: 99%

Reaction Conditions:

with thionyl chloride in dichloromethane at 20 - 25;Product distribution / selectivity;

Steps:

4
(Reference Example 4) 2-Hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine (5.0 g (23.7 mmol)) was dissolved in dichloromethane (40 ml), and thionyl chloride (4.23 g (35.6 mmol)) was added dropwise thereto so that the temperature did not exceed 25°C. Following stirring at room temperature, disappearance of the raw materials was confirmed by TLC, and 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine (6.23 g) was obtained by concentrating under a reduced pressure (yield: 99.0%).

References:

Eisai R&D Management Co., Ltd. EP1775292, 2007, A1 Location in patent:Page/Page column 13

675198-19-3 Synthesis

[4-(3-Methyoxypropoxy)-3-methyl-2-pyridinyl]methanol hydrochloride

675198-19-3
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$9.00/250mg

117977-20-5
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References

4-(3-Methoxypropoxy)-2,3-dimethylpyridine-N-oxide

117977-18-1
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$527.00/1g

117977-20-5
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References

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