2-Bromo-N-{3-[(4-methoxyphenyl)methoxy]phenyl}thieno[3,2-b]pyridin-7-amine synthesis
- Product Name:2-Bromo-N-{3-[(4-methoxyphenyl)methoxy]phenyl}thieno[3,2-b]pyridin-7-amine
- CAS Number:1228102-89-3
- Molecular formula:C21H17BrN2O2S
- Molecular Weight:441.34
![Thieno[3,2-b]pyridine, 2-bromo-7-chloro-](/CAS/GIF/225385-05-7.gif)
225385-05-7
59 suppliers
$158.00/250mg
![BenzenaMine, 3-[(4-Methoxyphenyl)Methoxy]-](/CAS/GIF/131770-85-9.gif)
131770-85-9
10 suppliers
$45.00/50mg
1228102-89-3
14 suppliers
inquiry
Yield:1228102-89-3 80%
Reaction Conditions:
in 1,2-dichloro-ethane;tert-butyl alcohol at 85; for 72 h;Sealed tube;
Steps:
P.23 The synthesis of 2-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-b]pyridin-7-amine
The synthesis of 2-bromo-N-(3-(4-methoxybenzyloxy)phenyl)thieno[3,2-b]pyridin-7-amine
The compound (0.18 g, 0.80 mmol) obtained from Preparation Example 1 was dissolved in 3 ml of dichloroethane and 3 ml of t-butanol and placed into a sealed tube.
The mixture was added with the synthesized compound (198 mg, 0.80 mmol) in example of synthesis 22-4 and stirred for next 3 days at 85° C.
After cooling to room temperature, the synthesized pale brown solid was washed by diethylether and the title compound (0.25 g, 80%) was obtained as a gray solid.
1H-NMR (400 MHz, CDCl3); δ 8.32 (d, J=5.2 Hz, 1H), 7.50 (s, 1H), 7.34 (d, J=7.6 Hz, 2H), 7.29 (t, J=8.0 Hz, 1H), 6.92 (d, J=7.6 Hz, 2H), 6.83-6.80 (m, 4H), 5.00 (s, 2H), 3.82 (s, 3H)
References:
US2013/72482,2013,A1 Location in patent:Paragraph 0290-0292
913377-45-4
11 suppliers
inquiry
1228102-89-3
14 suppliers
inquiry
![THIENO[3,2-B]PYRIDIN-7-OL](/StructureFile/ChemBookStructure4/GIF/CB2324535.gif)
69627-02-7
19 suppliers
inquiry
1228102-89-3
14 suppliers
inquiry
![7-Chlorothieno[3,2-b]pyridine](/CAS/GIF/69627-03-8.gif)
69627-03-8
174 suppliers
$6.00/100mg
1228102-89-3
14 suppliers
inquiry
554-84-7
22 suppliers
$12.00/5g
1228102-89-3
14 suppliers
inquiry