4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester synthesis
- Product Name:4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester
- CAS Number:1228689-61-9
- Molecular formula:C12H10BrNO3
- Molecular Weight:296.12
![Benzenepropanoic acid, 4-bromo-α-[1-(methylamino)ethylidene]-β-oxo-, methyl ester](/CAS/20180713/GIF/1423699-80-2.gif)
1423699-80-2
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1228689-61-9
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Yield:1228689-61-9 89%
Reaction Conditions:
with hydroxylamine hydrochloride;acetic acid for 2 h;Inert atmosphere;Reflux;
Steps:
I-A
To a stirred solution of I-4a (0.78 g, 2.5 mmol) in HO Ac (10 mL) was added hydroxylamine hydrochloride (0.17 g, 2.5 mmol) under nitrogen. After the addition, the solution was heated to reflux under nitrogen for 2 hrs. The solution was concentrated in vacuo to afford compound I-5a (0.66 g, yield 89%), which was used for next step without further purification.
References:
WO2013/25733,2013,A1 Location in patent:Paragraph 0404
85963-90-2
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1228689-61-9
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1228689-61-9
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