ChemicalBook CAS DataBase List 4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester

4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester synthesis

5synthesis methods

Product Name:4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester
CAS Number:1228689-61-9
Molecular formula:C12H10BrNO3
Molecular Weight:296.12

1423699-80-2 Synthesis

Benzenepropanoic acid, 4-bromo-α-[1-(methylamino)ethylidene]-β-oxo-, methyl ester

1423699-80-2
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4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-, Methyl ester

1228689-61-9
32 suppliers
$22.00/100mg

Yield:1228689-61-9 89%

Reaction Conditions:

with hydroxylamine hydrochloride;acetic acid for 2 h;Inert atmosphere;Reflux;

Steps:

I-A

To a stirred solution of I-4a (0.78 g, 2.5 mmol) in HO Ac (10 mL) was added hydroxylamine hydrochloride (0.17 g, 2.5 mmol) under nitrogen. After the addition, the solution was heated to reflux under nitrogen for 2 hrs. The solution was concentrated in vacuo to afford compound I-5a (0.66 g, yield 89%), which was used for next step without further purification.

References:

WO2013/25733,2013,A1 Location in patent:Paragraph 0404

Benzenepropanoic acid, α-acetyl-4-broMo-β-oxo-, Methyl ester

85963-90-2
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1228689-61-9
32 suppliers
$22.00/100mg

References

105-45-3
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$5.00/5g

1228689-61-9
32 suppliers
$22.00/100mg

References

586-76-5
482 suppliers
$10.00/1g

1228689-61-9
32 suppliers
$22.00/100mg

References

586-75-4
218 suppliers
$10.00/5g

1228689-61-9
32 suppliers
$22.00/100mg

References