2-(1,3-diMethyl-2,6-dioxo-1,2,3,6-tetrahydropyriMidin-4-ylaMino)ethyl 4-Methylbenzenesulfonate synthesis
- Product Name:2-(1,3-diMethyl-2,6-dioxo-1,2,3,6-tetrahydropyriMidin-4-ylaMino)ethyl 4-Methylbenzenesulfonate
- CAS Number:130634-04-7
- Molecular formula:C15H19N3O5S
- Molecular Weight:353.39
![6-[N-(2-Hydroxyethyl)amino]-1,3-dimethyl-2,4(1H,3H)-dione](/CAS/GIF/5770-44-5.gif)
Yield:130634-04-7 79.3%
Reaction Conditions:
with pyridine at 0; for 2 h;
Steps:
2 synthesis of 1,3-dimethyl-6-[2-(p-toluenesulfonyloxy)ethylamino]-2,4-(1H,3H)-pyrimidinedione
35 g (0.175 mol)L, 3-dimethyl-6- (2-hydroxyethyl) aminouracil was added140 ml of pyridine,Ice bath,Add 83. lg(0.438 m)P-toluenesulfonyl chloride,Keep the temperature below 0 ° C, plus finished, the insulation reaction 2h,The reaction solution was added to 1000 ml of ice water containing 50 g of potassium carbonate,20 ~ 30 ° C static crystallization 16h,Filtration was bright yellow crystals,Dried to give 1,3dimethyl-6- [2- (p-toluenesulfonyloxy) ethylamine] -2,4- (1-oxo-pyrimidinedione 49g ,Yield 79.3%
References:
CN103288751,2016,B Location in patent:Paragraph 0076; 0077
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227 suppliers
$6.00/1g
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15 suppliers
inquiry