Ethyl 2-(2-ethyl-6-hydroxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetate synthesis
- Product Name:Ethyl 2-(2-ethyl-6-hydroxy-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetate
- CAS Number:1414797-95-7
- Molecular formula:C16H20O4
- Molecular Weight:276.33
Yield:1414797-95-7 82%
Reaction Conditions:
with methanesulfonic acid at 20; for 16 h;
Steps:
116
10596] Methane sulphonic acid (6 mE) was added to a solution of product of Example 1168 (3.5 g, 14.17 mmol) in ethanol (50 mE), and the reaction mixture was stirred at room temperature for 16 h. Ethanol was removed from reaction mixture under reduced pressure, and residue was diluted with ethyl acetate and washed with brine solution. The organic layer was dried over sodium sulphate, filtered and removed under under reduced pressure to give crude product which was purified by flash chromatography using 20% ethyl acetate in pet ether to afford title compound (3.2 g, 82%) as solid. ‘H NMR (300 MHz, CDC13): ? 10.2 (s, 1H), 8.0 (d, J=8.4 Hz, 1H), 6.7 (d, J=7.4 Hz, 1H), 6.6 (s, 1H), 4.0 (m, 2H), 3.2-2.7 (m, 3H), 2.5-2.3 (m, 2H), 2.2-1.9 (m, 1H), 1.8-1.6 (m, 2H), 1.2 (t, J=7.2 Hz, 3H), 0.8 (t, J=7.6 Hz, 3H).
References:
US2015/307445,2015,A1 Location in patent:Paragraph 0590; 0595; 0596
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