methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate synthesis
- Product Name:methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate
- CAS Number:1421312-36-8
- Molecular formula:C20H18N2O5
- Molecular Weight:366.37
1421312-35-7
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Yield: 85.1%
Reaction Conditions:
with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;triethylamine in dichloromethane;water at 40;
Steps:
4; 1-7 Example 4 Preparation of Compound F (R is a methyl group)
Weigh 2.0 g of Compound D in a three-necked flask containing 20 ml of dichloromethane: water in 1:1 solution.2.5 g of EDCI, 1.8 g of HOBt, 1.3 g of triethylamine and 1.1 g of glycine methyl ester hydrochloride were successively added, and the mixture was heated at 40 ° C overnight.After the reaction is completed, the reaction solution is placed in a separatory funnel and extracted and purified. The upper layer of methylene chloride is separated and dried to give a yellow solid.Material F (yield 85.1%, purity 97.5%).The lower aqueous layer can continue to be used as a solvent for the preparation of compound F.
References:
Nanjing Zhengda Tianqing Pharmaceutical Co., Ltd.;Nanjing Baimai Biological Co., Ltd.;Zhu Yucheng;Zhao Mingli;Chai Yuzhu;Zhang Tianlong;Shi Xueyi;Wang Yuan CN109956901, 2019, A Location in patent:Paragraph 0067-0070; 0076-0082
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31643-49-9
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38791-62-7
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