4(1H)-Quinazolinone, 3-cyclopropyl-2,3-dihydro-2-thioxo- synthesis
- Product Name:4(1H)-Quinazolinone, 3-cyclopropyl-2,3-dihydro-2-thioxo-
- CAS Number:146381-56-8
- Molecular formula:C11H10N2OS
- Molecular Weight:218.27
30385-94-5
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146381-56-8
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Yield:146381-56-8 90%
Reaction Conditions:
with carbon disulfide;potassium hydroxide in ethanol; for 3 h;Reflux;
Steps:
General Experimental Procedure for 2-thioxo- 2,3-dihydroquinazolin-4(1H)-one derivatives
General procedure: A solution of isatoic anhydride (1 mmol) and appropriate amine (1 mmol) in 10 ml EtOH was stirred at reflux for 3 h. Then, a mix- ture of carbon disulfide (2 mmol) and KOH (1 mmol) was added to the reaction mixture and stirring continued under the same condi- tions for 3 h. The reaction mixture was cooled to room tempera- ture and poured into 20 ml water. The precipitate was collected by filtration, washed with water, and recrystallized using EtOH to give desirable product as colorless crystals.
References:
Adibi, Hossein;Asgari, Mohammad Sadegh;Attarroshan, Mahshid;Farid, Sara Moghadam;Hamedifar, Haleh;Hosseini, Samanesadat;Iraji, Aida;Kabiri, Maryam;Khoshneviszadeh, Mehdi;Larijani, Bagher;Mahdavi, Mohammad;Moayedi, Seyedeh Sara;Moazzam, Ali;Pirhadi, Somayeh;Sakhteman, AmirHossein;Sepehri, Nima [Journal of Molecular Structure,2022,vol. 1253,art. no. 132283]
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146381-56-8
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146381-56-8
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$60.00/50mg
118-48-9
430 suppliers
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146381-56-8
15 suppliers
$60.00/50mg