Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester synthesis
- Product Name:Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- CAS Number:178306-47-3
- Molecular formula:C17H18O4
- Molecular Weight:286.32
67-56-1
781 suppliers
$7.29/5ml-f
76527-25-8
57 suppliers
$140.00/100mg
178306-47-3
155 suppliers
$60.00/500mg
Yield:178306-47-3 88%
Reaction Conditions:
with boron trifluoride diethyl etherate at 0 - 20; for 14 h;
Steps:
1 Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate
5 g (19.6 mmol) of methyl 3,3-diphenyl-2,3-epoxypropionate,Was dissolved in 50 ml of anhydrous methanol,0.1 ml of boron trifluoride etherate was added at 0 ° C.The mixture was stirred at 0 ° C. for 2 hours,The mixture was further stirred at room temperature for 12 hours.The solvent was distilled off, The residue was placed in ethyl acetate,Washed with sodium bicarbonate and water,And dried over magnesium sulfate.After removing the solvent by distillation,5.5 g (88%) of a pale yellow oil remained.
References:
ABBVIE DEUTSCHLAND GMBH & CO. KG;RIECHERS, HARTMUT;KLINGE, DAGMAR;AMBERG, WILHELM;KLING, ANDREAS;MULLER, STEFAN;BAUMANN, ERNST;RHEINHEIMER, JOACHIM;VOGELBACHER, UWE JOSEF;WERNET, WOLFGANG;UNGER, LILIANE;RASCHACK, MANFRED JP5700378, 2015, B2 Location in patent:Paragraph 0062
76527-25-8
57 suppliers
$140.00/100mg
178306-47-3
155 suppliers
$60.00/500mg
119-61-9
816 suppliers
$5.00/10g
96-34-4
366 suppliers
$10.00/25g
178306-47-3
155 suppliers
$60.00/500mg
178306-52-0
198 suppliers
$106.00/100mg
178306-47-3
155 suppliers
$60.00/500mg
119-61-9
816 suppliers
$5.00/10g
178306-47-3
155 suppliers
$60.00/500mg