[2,2']BITHIOPHENYL-5-YL-METHANOL synthesis
- Product Name:[2,2']BITHIOPHENYL-5-YL-METHANOL
- CAS Number:3515-30-8
- Molecular formula:C9H8OS2
- Molecular Weight:196.29
3779-27-9
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Yield:3515-30-8 99%
Reaction Conditions:
with sodium borohydrid in methanol;
Steps:
31 Preparation of 5-hydroxymethyl-2,2'-bithiophene
Preparation of 5-hydroxymethyl-2,2'-bithiophene To a solution of 5-formyl-2,2'-bithiophene (20 g) in methanol (50 ml) was added sodium borohydride. The reaction mixture was stirred at room temperature and monitored with thin layer chromatography until the reaction completed. After removal of methanol, water was added to dissolve inorganic salts and extracted with dichloromethane. The extract was washed with brine, dried over anhydrous magnesium sulfate, concentrated to give product (20.1 g, 99%), melting point 52°-53° C. Spectral Data: 1 H NMR (DMSO-D6), δ value 7.4-6.6 (m, 5H), 5.51 (t, 2H), 4.5 (d, 2H)
References:
US5578636,1996,A
492-97-7
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3480-11-3
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