2-(2-Pyridyl)-4-trifluoromethylimidazole synthesis
- Product Name:2-(2-Pyridyl)-4-trifluoromethylimidazole
- CAS Number:33468-85-8
- Molecular formula:C9H6F3N3
- Molecular Weight:213.16
1121-60-4
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Yield:33468-85-8 33%
Reaction Conditions:
Stage #1: 1,1-dibromo-3,3,3-trifluoroacetonewith sodium acetate for 0.5 h;Heating;Hydrolysis;
Stage #2: pyridine-2-carbaldehydewith ammonium hydroxide in methanol at 20; for 20 h;cyclocondensation;
References:
Dhainaut, Alain;Tizot, André;Raimbaud, Eric;Lockhart, Brian;Lestage, Pierre;Goldstein, Solo [Journal of Medicinal Chemistry,2000,vol. 43,# 11,p. 2165 - 2175]