1-Methylimidazole synthesis
- Product Name:1-Methylimidazole
- CAS Number:616-47-7
- Molecular formula:C4H6N2
- Molecular Weight:82.1
(CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O
The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation.
H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I
[H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI
35487-17-3
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Yield:616-47-7 98.5%
Reaction Conditions:
with sodium methylate
Steps:
36
Lower layer separated in Example 1 was added with 20.84 g (0.521 moles) of sodium hydroxide at room temperature, followed by stirring for 1 hour. 1- Methylimidazole was recovered (recovery 97.6%) by distilling the remaining solution at a reduced pressure after the produced NaCl was filtered; 1-Methy limidazole was recovered by following the same procedure as described in Example 31 except by using sodium methoxide (NaOCHs) instead of sodium hydroxide, and the recovery was 98.5%.
References:
WO2008/1985,2008,A1 Location in patent:Page/Page column 11
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