
2,3-DICHLOROBENZYL BROMIDE synthesis
- Product Name:2,3-DICHLOROBENZYL BROMIDE
- CAS Number:57915-78-3
- Molecular formula:C7H5BrCl2
- Molecular Weight:239.92

38594-42-2

57915-78-3
General procedure for the synthesis of 2,3-dichlorobenzyl bromide from 2,3-dichlorobenzyl alcohol: Phosphorus tribromide (40.7 g, 0.151 mol) was added slowly and dropwise to a solution of 2,3-dichlorobenzyl alcohol (75 g, 0.431 mol) in toluene (800 ml) at room temperature with continuous stirring. The reaction mixture was continued to be stirred at room temperature for 2 hours and then concentrated. The concentrated residue was neutralized with aqueous sodium bicarbonate and subsequently extracted with dichloromethane (300 ml x 3). The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated to give 2,3-dichlorobenzyl bromide (84.7 g, 83% yield) as a dark solid.

38594-42-2
109 suppliers
$12.00/250mg

7789-60-8
399 suppliers
$10.40/25G

57915-78-3
108 suppliers
$9.00/1g
Yield: 83%
Reaction Conditions:
in toluene
Steps:
35.c c)
c)
1-(bromomethyl)-2,3-dichlorobenzene
To a solution of (2,3-dichlorophenyl)methanol (75 g, 0.431 mol), in toluene (800 mL), tribromophosphine (40.7 g, 0.151 mol) was added dropwise at room temperature with stirring.
Then the reaction mixture was stirred at room temperature for 2 h and concentrated.
The resulting residue was neutralized with aq. NaHCO3 and extracted with DCM (300 mL*3).
The organic layer was washed with brine, dried over Na2SO4, filtered and the filtrate was concentrated to provide the titled compound (84.7 g, 83%), as a deep red solid.
References:
GlaxoSmithKline LLC;Lin, Hong;Luengo, Juan Ignacio;Moore, Michael Lee;Qu, Junya;Rivero, Ralph A.;Tedesco, Rosanna;Yu, Hongyi US9096605, 2015, B2

38594-42-2
109 suppliers
$12.00/250mg

57915-78-3
108 suppliers
$9.00/1g

32768-54-0
265 suppliers
$9.00/25g

57915-78-3
108 suppliers
$9.00/1g

50-45-3
440 suppliers
$7.00/10g

57915-78-3
108 suppliers
$9.00/1g

2905-54-6
96 suppliers
$9.00/1g

57915-78-3
108 suppliers
$9.00/1g