ChemicalBook CAS DataBase List 2,3-DICHLOROBENZYL BROMIDE

2,3-DICHLOROBENZYL BROMIDE synthesis

5synthesis methods

Product Name:2,3-DICHLOROBENZYL BROMIDE
CAS Number:57915-78-3
Molecular formula:C7H5BrCl2
Molecular Weight:239.92

38594-42-2 Synthesis

38594-42-2
106 suppliers
$12.00/250mg

7789-60-8 Synthesis

7789-60-8
373 suppliers
$10.40/25G

57915-78-3
107 suppliers
$9.00/1g

Yield: 83%

Reaction Conditions:

in toluene

Steps:

35.c c)
c)
1-(bromomethyl)-2,3-dichlorobenzene
To a solution of (2,3-dichlorophenyl)methanol (75 g, 0.431 mol), in toluene (800 mL), tribromophosphine (40.7 g, 0.151 mol) was added dropwise at room temperature with stirring.
Then the reaction mixture was stirred at room temperature for 2 h and concentrated.
The resulting residue was neutralized with aq. NaHCO₃ and extracted with DCM (300 mL*3).
The organic layer was washed with brine, dried over Na₂SO₄, filtered and the filtrate was concentrated to provide the titled compound (84.7 g, 83%), as a deep red solid.

References:

GlaxoSmithKline LLC;Lin, Hong;Luengo, Juan Ignacio;Moore, Michael Lee;Qu, Junya;Rivero, Ralph A.;Tedesco, Rosanna;Yu, Hongyi US9096605, 2015, B2

38594-42-2 Synthesis

38594-42-2
106 suppliers
$12.00/250mg

57915-78-3
107 suppliers
$9.00/1g

References

32768-54-0 Synthesis