ChemicalBook CAS DataBase List 2,3-DICHLOROBENZYL BROMIDE

2,3-DICHLOROBENZYL BROMIDE synthesis

5synthesis methods

Product Name:2,3-DICHLOROBENZYL BROMIDE
CAS Number:57915-78-3
Molecular formula:C7H5BrCl2
Molecular Weight:239.92

38594-42-2

57915-78-3

General procedure for the synthesis of 2,3-dichlorobenzyl bromide from 2,3-dichlorobenzyl alcohol: Phosphorus tribromide (40.7 g, 0.151 mol) was added slowly and dropwise to a solution of 2,3-dichlorobenzyl alcohol (75 g, 0.431 mol) in toluene (800 ml) at room temperature with continuous stirring. The reaction mixture was continued to be stirred at room temperature for 2 hours and then concentrated. The concentrated residue was neutralized with aqueous sodium bicarbonate and subsequently extracted with dichloromethane (300 ml x 3). The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated to give 2,3-dichlorobenzyl bromide (84.7 g, 83% yield) as a dark solid.

38594-42-2 Synthesis

38594-42-2
112 suppliers
$12.00/250mg

7789-60-8 Synthesis

7789-60-8
402 suppliers
$10.40/25G

57915-78-3
109 suppliers
$9.00/1g

Yield: 83%

Reaction Conditions:

in toluene

Steps:

35.c c)
c)
1-(bromomethyl)-2,3-dichlorobenzene
To a solution of (2,3-dichlorophenyl)methanol (75 g, 0.431 mol), in toluene (800 mL), tribromophosphine (40.7 g, 0.151 mol) was added dropwise at room temperature with stirring.
Then the reaction mixture was stirred at room temperature for 2 h and concentrated.
The resulting residue was neutralized with aq. NaHCO₃ and extracted with DCM (300 mL*3).
The organic layer was washed with brine, dried over Na₂SO₄, filtered and the filtrate was concentrated to provide the titled compound (84.7 g, 83%), as a deep red solid.

References:

GlaxoSmithKline LLC;Lin, Hong;Luengo, Juan Ignacio;Moore, Michael Lee;Qu, Junya;Rivero, Ralph A.;Tedesco, Rosanna;Yu, Hongyi US9096605, 2015, B2

38594-42-2 Synthesis

38594-42-2
112 suppliers
$12.00/250mg

57915-78-3
109 suppliers
$9.00/1g

References

32768-54-0 Synthesis