(2,3-dihydrobenzofuran-6-yl)methanol synthesis
- Product Name:(2,3-dihydrobenzofuran-6-yl)methanol
- CAS Number:1083168-69-7
- Molecular formula:C9H10O2
- Molecular Weight:150.17
1083168-68-6
17 suppliers
inquiry
1083168-69-7
55 suppliers
$45.00/10mg
Yield:1083168-69-7 92%
Reaction Conditions:
Stage #1: methyl 2,3-dihydrobenzofuran-6-carboxylatewith lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 1 h;
Stage #2: with sodium hydroxide;water in tetrahydrofuran;
Steps:
G.f
Stepf: (2,3-Dihydrobenzofuran-6-yl)methanol; To a stirred solution of lithium aluminium hydride (6.1 g, 250 mmol) in THF(300 mL) was added a solution of methyl 2,3-dihydrobenzofuran-6-carboxylate (17.8 g, 100 mmol) in THF at 0°C. The mixture was stirred at room temperature for 1 h. A saturated aqueous NaOH solution was added and the mixture was extracted with ethyl acetate. The combined organic layers were washed with brine and dried over Na2SO4, filtered and concentrated to afford (2,3-dihydrobenzofuran-6-yl)methanol (13.8 g, 92.0% yield). 1H NMR (400 MHz, CDCl3) δ: 7.17 (d, J= 7.2, IH), 6.84 (d, J= 7.2, IH), 6.81 (s, IH), 4.62 (s, 2H), 4.58 (t, J= 8.4, 2H), 3.20 (t, J= 8.4, 2H),) 1.67 (br s, IH).
References:
WO2008/141119,2008,A2 Location in patent:Page/Page column 77; 79
50-00-0
895 suppliers
$10.00/25g
189035-22-1
79 suppliers
$65.00/50mg
1083168-69-7
55 suppliers
$45.00/10mg
13196-11-7
106 suppliers
$185.00/250mg
1083168-69-7
55 suppliers
$45.00/10mg
![6-Hydroxy-2,3-dihydrobenzo[b]furan-3-one](/CAS/GIF/6272-26-0.gif)
6272-26-0
206 suppliers
$9.00/1g
1083168-69-7
55 suppliers
$45.00/10mg
588703-29-1
67 suppliers
$122.00/100mg
1083168-69-7
55 suppliers
$45.00/10mg