2-(4-Aminophenyl)ethanol synthesis
- Product Name:2-(4-Aminophenyl)ethanol
- CAS Number:104-10-9
- Molecular formula:C8H11NO
- Molecular Weight:137.18
100-27-6
104-10-9
The general procedure for the synthesis of p-aminophenethyl alcohol from p-nitrophenylethanol is as follows: 1. In a 1000 mL three-necked flask equipped with a thermometer, a mechanical stirrer, and a reflux condenser, 10 mL of 0.1 M hydrochloric acid solution, 500 mL of methanol, and 2 g of Pt-SnO2/C catalyst were added and heated to 68°C. The reaction system was then heated to 68°C. The reaction system was then heated to 68°C. 2. 100 g of p-nitrophenyl ethanol was added to the reaction system, the pH was adjusted to 7 with 30% NaOH solution, stirred and water was added slowly and dropwise, and 75 g of distillate was collected, heated to reflux, and the reflux temperature was maintained at 68°C. The reaction was carried out by thin layer chromatography. 3. The progress of the reaction was monitored by thin layer chromatography (TLC) until the disappearance of the feedstock point indicated the completion of the reaction. At the end of the reaction, the reaction mixture was filtered to remove the catalyst, cooled and the methanol was recovered by atmospheric distillation. 4. The reaction mixture was cooled to 20°C, appropriate amount of water and a small amount of NaOH solution were added and processed by freezing and vacuum drying to obtain 4-aminophenethyl alcohol as a white solid.
100-27-6
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104-10-9
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Yield:104-10-9 99.7%
Reaction Conditions:
with hydrogenchloride;hydrazine hydrate;sodium hydroxide in methanol;water at 68; pH=7;Reagent/catalyst;pH-value;
Steps:
1-10 Example 1
Intermediate 4-amino ethanol synthesis method, characterized in that the method comprises the following steps: Step 1, is provided with a thermometer to, mechanical stirring, reflux condenser 1000 ml three-port flask, add 10 ml concentration 0.1 M hydrochloric acid solution, 500 ml methanol and 2 g catalyst Pt - SnO2 /C, heating up to 68 °C; Step 2, to the ethanol solution is added to the nitrobenzene ethanol 100 g, for 30% concentration NaOH to adjust the pH=7, after stir slowly dropping water gathers jing 75 g, heating to reflux, the reflux temperature is 68 °C; Step 3, thin-layer chromatography monitoring reaction, to point the disappearance of the raw material, the end of the reaction, the reaction mixture is filtered to remove cooling and outputs Catalyst, normal pressure distillation recovery methanol; Step 4, the above-mentioned mixed system is cooled to 20 °C, adding proper amount of water and a small amount of NaOH solution, by freezing, vacuum drying to obtain white 4-amino ethanol.
References:
CN108840802,2018,A Location in patent:Paragraph 0008; 0021-0029
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