ChemicalBook CAS DataBase List 2,4-DICHLOROBENZOPHENONE

2,4-DICHLOROBENZOPHENONE synthesis

10synthesis methods

Product Name:2,4-DICHLOROBENZOPHENONE
CAS Number:19811-05-3
Molecular formula:C13H8Cl2O
Molecular Weight:251.11

100-58-3
189 suppliers
$18.00/10ml

89-75-8
267 suppliers
$24.00/25g

19811-05-3
120 suppliers
$40.00/5G

Yield:19811-05-3 94 %

Reaction Conditions:

with copper(II) catalyst immobilized on poly[3-(carboxypropy)thiophene-2,5-diyl] in tetrahydrofuran at 0 - 20;Inert atmosphere;Kumada Cross-Coupling;

Steps:

2.4 Typical Procedure for the Coupling Reaction of Grignard Reagent with Acid Chloride Using Cu(at)PCPT

General procedure: In a round-bottomed flask, Cu(at)PCPT (40mg) was placed then purged with Ar gas. Next, organomagnesium reagent(4.5mmol) and 5mL of THF was added into the flask. The reaction fask was cooled down to 0°C with an ice-bath. Withbeing stirred at 0°C under Ar gas pressure, acid chloride(3.0mmol) was added neat into the mixture via a syringe.The resulting mixture was gradually allowed to warm up toroom temperature over 2.0h. After a suitable work up andpurifcation using fash column chromatrography (2% ethylacetate/98% hexanes), the desired product was isolated. Characterizationdata (1H and 13C NMR spectra) of the ketones areprovided in SI.

References:

Soo-Jung, Kwak;Seong-Ryu, Joo;Ji-Hye, Kang;Shin, Ueon Sang;Seung-Hoi, Kim [Catalysis Letters,2022]