ChemicalBook CAS DataBase List 1,3-Dichlorobenzene

1,3-Dichlorobenzene synthesis

12synthesis methods

Product Name:1,3-Dichlorobenzene
CAS Number:541-73-1
Molecular formula:C6H4Cl2
Molecular Weight:147

1,3-Dichlorobenzene is prepared from o-chloroaniline through diazotization and displacement reaction.
Add o-chloroaniline and hydrochloric acid into the reaction pot, mix evenly below 25°C, cool to 0°C, drop in sodium nitrite solution, control the temperature at 0-5°C, stop adding when the potassium iodide starch indicator turns blue, and obtain diazonium salt solution. Then add the diazonium salt solution into the hydrochloric acid solution of cuprous chloride at 0～5℃, stir well, heat up to 60～70℃ and react for 1h, after cooling, let stand for stratification, and use 5% sodium hydroxide for the oil layer. Repeated washing with water, dehydration with anhydrous calcium chloride, fractional distillation, and collection of fractions at 177-183 °C to obtain the product 1,3-dichlorobenzene.

121-73-3
20 suppliers
$10.00/1g

541-73-1
388 suppliers
$22.00/25G

Yield:541-73-1 474.6 kg

Reaction Conditions:

with chlorine at 190;Large scale;Temperature;

Steps:

1.3; 2.3; 3.3; 4.3

517kg m-chloronitrobenzene and 116kg chlorine gas are continuously put into the tower and then heated to 190°C, meanwhile m-dichlorobenzene and tail gas are continuously distilled out,The tail gas enters the dilute nitric acid tower and is used for nitrification in the next section.Then, distill off the m-dichlorobenzene that has been distilled off and collect it for distillation.474.6kg of dichlorobenzene between finished products;

References:

CN111153779,2020,A Location in patent:Paragraph 0026; 0030; 0036; 0040; 0046; 0050; 0056; 0060