2-(4-(methoxycarbonyl)phenyl)acetic acid synthesis
- Product Name:2-(4-(methoxycarbonyl)phenyl)acetic acid
- CAS Number:22744-12-3
- Molecular formula:C10H10O4
- Molecular Weight:194.18
52787-14-1
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22744-12-3
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Yield: 94.4%
Reaction Conditions:
with lithium hydroxide monohydrate;water in tetrahydrofuran;ethanol at 25; for 10 h;
Steps:
5 Example 5; preparation of 2- (4- (methoxycarbonyl) phenyl)acetic acid (5)
2- (4- (methoxycarbonyl) phenyl) acetic acid (58,24.04 dirty 1) to the reaction flask, 31111 water, 31111 5ml tetrahydrofuran and a mixed solvent of ethanol raw materials were dissolved. Was then added Η0Η-Η20 (1.068,25.24ππο1) α25 ° C was stirred for 10 hours the reaction is substantially complete. The solution was spin-off in tetrahydrofuran and ethanol, followed by addition of 26ml of dilute hydrochloric acid (lmmol / L), and a white precipitate formed, suction, infrared drying to give a white solid 4.4g, 94.4% yield
References:
China Pharmaceutical University;Xiang, Hua;Xu, Pei;Wang, Wenbin;Qian, Zhouyang;Chen, Mingqi;You, Qidong CN105541777, 2016, A Location in patent:Paragraph 0015; 0062; 0063; 0064
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22744-12-3
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22744-12-3
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