ChemicalBook CAS DataBase List 2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE

2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE synthesis

6synthesis methods

Product Name:2-AMINO-5-BROMO-4-PHENYLPYRIMIDINE
CAS Number:85658-55-5
Molecular formula:C10H8BrN3
Molecular Weight:250.09

2305-87-5

85658-55-5

To a 100 mL round bottom flask was added 4-phenylpyrimidin-2-amine (0.4 g, 0.0023 mol) and a solvent mixture of acetonitrile and chloroform (1:1, 20 mL). Subsequently, N-bromosuccinimide (0.499 g, 0.0028 mol) was added to the same flask. The reaction mixture was stirred at room temperature for 20 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the residue. The residue was extracted by partitioning between ethyl acetate and water. The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the crude product. The crude product was purified by column chromatography using 60-120 mesh silica gel as stationary phase and 40% hexane solution of ethyl acetate as eluent to give 2-amino-5-bromo-4-phenylpyrimidine [0.3 g, 51% yield]. The product was confirmed by NMR hydrogen spectroscopy (300 MHz, DMSO-d6): δ 8.43 (s, 1H), 7.65-7.61 (m, 2H), 7.49-7.42 (m, 3H), 6.97 (brs, 2H); Liquid Chromatography-Mass Spectrometry (LC-MS) analysis showed that [M+2H]+ m/z 251.9.

7752-82-1 Synthesis

7752-82-1
433 suppliers
$13.00/25g

98-80-6 Synthesis

98-80-6
736 suppliers
$5.00/5g

85658-55-5
44 suppliers
$45.00/25mg

Yield:85658-55-5 67%

Reaction Conditions:

with dipotassium peroxodisulfate in water;acetone at 160; for 0.75 h;Sealed tube;

References:

Thatikonda, Thanusha;Singh, Umed;Ambala, Srinivas;Vishwakarma, Ram A.;Singh, Parvinder Pal [Organic and Biomolecular Chemistry,2016,vol. 14,# 18,p. 4312 - 4320]

2305-87-5
97 suppliers
$14.14/250mgs:

85658-55-5
44 suppliers
$45.00/25mg

References

7752-82-1 Synthesis

7752-82-1
433 suppliers
$13.00/25g

24388-23-6 Synthesis