2-Amino-5-chloropyridine-3-carboxylic acid synthesis
- Product Name:2-Amino-5-chloropyridine-3-carboxylic acid
- CAS Number:58584-92-2
- Molecular formula:C6H5ClN2O2
- Molecular Weight:172.57
38496-18-3
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$6.00/1g
58584-92-2
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$18.00/250mg
Yield:58584-92-2 93%
Reaction Conditions:
with ammonium hydroxide at 130; for 12 h;Sealed tube;
Steps:
68 2-Amino-6-chloropyridine-3-carboxylic acid
A solution of 2,6-dichloropyridine-3-carboxylic acid (3 g, 0.0157 mol) in aqueous ammonia (30 mL) was heated in a sealed tube at 130°C for 12 h. The reaction mixture was concentrated and the resulting crude solid was triturated with diethyl ether to afford the title compound (2.5 g, 93%). δΗ (400 MHz, DMSO-de) 8.02 (d, J 8.0 Hz, IH), 7.55 (s, 2H), 6.62 (d, J 8.0 Hz, IH). LCMS: mlz 173 (97.70%)
References:
UCB BIOPHARMA SPRL;BRACE, Gareth Neil;CHOVATIA, Prafulkumar Tulshibhai;FOULKES, Gregory;JOHNSON, James Andrew;JONES, Severine Danielle;KROEPLIEN, Boris;LECOMTE, Fabien Claude;LOKE, Pui Leng;LOWE, Martin Alexander;MANDAL, Ajay;NORMAN, Timothy John;PALMER, Christopher Francis;PÉREZ-FUERTES, Yolanda;PORTER, John Robert;SMYTH, Donald;TRANI, Giancarlo;UDDIN, Muhammed;ZHU, Zhaoning WO2016/198400, 2016, A1 Location in patent:Page/Page column 65
60-35-5
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38496-18-3
383 suppliers
$6.00/1g
58584-92-2
150 suppliers
$18.00/250mg
849805-25-0
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58584-92-2
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$18.00/250mg
64-17-5
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52471-07-5
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1384985-48-1
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58584-92-2
150 suppliers
$18.00/250mg
52471-07-5
66 suppliers
inquiry
58584-92-2
150 suppliers
$18.00/250mg