![](/CAS/GIF/5521-56-2.gif)
2-Amino-6-methylpyrazine synthesis
- Product Name:2-Amino-6-methylpyrazine
- CAS Number:5521-56-2
- Molecular formula:C5H7N3
- Molecular Weight:109.13
![(6-CHLOROPYRAZIN-2-YL)ACETIC ACID](/CAS/GIF/930798-25-7.gif)
930798-25-7
88 suppliers
$72.00/250mg
![2-Amino-6-methylpyrazine](/CAS/GIF/5521-56-2.gif)
5521-56-2
136 suppliers
$33.00/200mg
Yield: 71%
Reaction Conditions:
with ammonia in water at 180; under 26252.6 Torr; for 8 h;sealed vessel;
Steps:
1.c
60ml) at O0C was added, diethylmalonate (2.1moleq) in THF (60ml) and 2,6- dichloropyrazine (2Og) in THF (40ml). The mixture was then heated to reflux for 18hrs before being allowed to cool and 2M Hydrochloric acid (100ml) added. The resulting two layers were separated and the THF layer partially concentrated under vacuum to give a solution containing 2-(6-chloro-pyrazin-2-yl)-malonic acid diethyl ester. This solution was EPO
References:
ASTRAZENECA AB WO2007/35153, 2007, A1 Location in patent:Page/Page column 2; 4-5
![DIMETHYLZINC](/CAS/GIF/544-97-8.gif)
544-97-8
131 suppliers
$130.00/5g
![2-Chloro-6-aminopyrazine](/CAS/GIF/33332-28-4.gif)
33332-28-4
293 suppliers
$9.00/1g
![2-Amino-6-methylpyrazine](/CAS/GIF/5521-56-2.gif)
5521-56-2
136 suppliers
$33.00/200mg
![Methylmagnesium Bromide](/CAS/GIF/75-16-1.gif)
75-16-1
267 suppliers
$12.00/10ml
![2-Chloro-6-aminopyrazine](/CAS/GIF/33332-28-4.gif)
33332-28-4
293 suppliers
$9.00/1g
![2-Amino-6-methylpyrazine](/CAS/GIF/5521-56-2.gif)
5521-56-2
136 suppliers
$33.00/200mg
![2-AMINO-3,5-DIBROMO-6-METHYLPYRAZINE](/CAS/GIF/74290-66-7.gif)
74290-66-7
69 suppliers
$76.00/250mg
![2-Amino-6-methylpyrazine](/CAS/GIF/5521-56-2.gif)
5521-56-2
136 suppliers
$33.00/200mg
![2-Chloro-6-methylpyrazine](/CAS/GIF/38557-71-0.gif)
38557-71-0
168 suppliers
$5.00/250mg
![2-Amino-6-methylpyrazine](/CAS/GIF/5521-56-2.gif)
5521-56-2
136 suppliers
$33.00/200mg