ChemicalBook CAS DataBase List 2-amino-alpha,alpha,alpha-trifluoro-p-creso

2-amino-alpha,alpha,alpha-trifluoro-p-creso synthesis

5synthesis methods

Product Name:2-amino-alpha,alpha,alpha-trifluoro-p-creso
CAS Number:454-81-9
Molecular formula:C7H6F3NO
Molecular Weight:177.12

400-99-7 Synthesis

400-99-7
176 suppliers
$19.00/5g

7772-99-8 Synthesis

7772-99-8
365 suppliers
$10.00/25g

2-amino-alpha,alpha,alpha-trifluoro-p-creso

454-81-9
122 suppliers
$22.00/250mg

Yield: 83%

Reaction Conditions:

in ethanol

Steps:

117.a a)
a) Preparation of 2-amino-4-trifluoromethylphenol A mixture of 4-trifluoromethyl-2-nitrophenol(1.0 g, 4.8 mmol) and tin (II) chloride (5.4 g, 24.2 mmol) in ethanol(150 mL) was heated at 80° C. under argon. After 2 hours, the starting material had disappeared and the solution was allowed to cool down and then poured into ice. The pH was made slightly basic (pH7-8), by addition of solid NaOH, before being extracted with ethyl acetate. The organic phase was washed with brine, dried over MgSO₄ and filtered. The solvent was evaporated and chromatography of the resulting solid on silica gel (4% MeOH/CH₂ Cl₂) gave the desired product(708 mg, 83%). ¹ H NMR (CD₃ OD): δ 6.87 (s, 1H), 6.80 (d, 1H), 6.69 (d, 1H).

References:

SmithKline Beecham Corporation US5886044, 1999, A

400-99-7 Synthesis

400-99-7
176 suppliers
$19.00/5g

454-81-9
122 suppliers
$22.00/250mg

References

121-17-5 Synthesis