ChemicalBook CAS DataBase List 2-Bromo-2′-hydroxyacetophenone

2-Bromo-2′-hydroxyacetophenone synthesis

8synthesis methods

Product Name:2-Bromo-2′-hydroxyacetophenone
CAS Number:2491-36-3
Molecular formula:C8H7BrO2
Molecular Weight:215.04

582-24-1 Synthesis

582-24-1
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$8.00/5g

2491-36-3
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$10.00/1g

Yield: 60%

Reaction Conditions:

with bromine;acetic acid for 2 h;Reflux;

Steps:

Synthesis of 3-bromoacetyl-4-hydroxy-6-methyl-2H-pyran-2-one 2c:
General procedure: A solution of bromine (0.27 mL, 5 mmol) inacetic acid (10 mL) is added stepwise to a solution of DHA 1 (0.84 g, 5 mmol) in acetic acid (20 mL). After a reflux of 2h, the reaction mixture was poured into water (100 mL) and ice (50 g). The obtained solid was filtered-off andrecrystallized from a 1:1 mixture of hexane-chloroform, being compound 2c obtained as yellow crystals (0.75 g, 61%):mp 117°C (mp 118-119 ).

References:

Lechani, Nawel;Hamdi, Maamar;Kheddis-Boutemeur, Baya;Talhi, Oualid;Laichi, Yacine;Bachari, Khaldoun;Silva, Artur M. S. [Synlett,2018,vol. 29,# 11,p. 1502 - 1504] Location in patent:supporting information