ChemicalBook CAS DataBase List 2-Bromo-9-fluorenone

2-Bromo-9-fluorenone synthesis

12synthesis methods

Product Name:2-Bromo-9-fluorenone
CAS Number:3096-56-8
Molecular formula:C13H7BrO
Molecular Weight:259.1

The synthesis of 2-Bromo-9-fluorenone is as follows：the 9-fluorenone (10mmol), the phase transfer catalyst (1.5mmol fourteen alkyl trimethyl ammonium chloride) and brominated aqueous ammonium solution (30 wt %, 25mmol ammonium bromide) mixing and heating system temperature to 75 °C, in 1h is divided into three time 11mmol potassium bromate, to three times the weight ratio of 1:3:1, to maintain the system temperature to continue reaction 3h, wherein the 9-fluorenone, ammonium bromide, the molar ratio of potassium bromate 1 : 2.5: 1.1 ; 9-fluorenone, and fourteen alkyl trimethyl ammonium chloride (phase-transfer catalyst) molar ratio of 1 : 0.15; 2) after the reaction, to room temperature, by adding 20% aqueous solution of sodium sulfite ( eliminates the bromine fluid ), is filtered, the filter cake washing water And dried to obtain yellow solid of 2-Bromo-9-fluorenone, the yield is 99.2%.

486-25-9 Synthesis

486-25-9
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$5.00/25g

3096-56-8
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$10.00/1g

Yield:3096-56-8 99.2%

Reaction Conditions:

with potassium bromate;tetra-n-butyl-ammonium chloride;ammonium bromide in lithium hydroxide monohydrate at 75; for 6 h;Temperature;

Steps:

3 Embodiment 3 2-bromo-9-fluorenone, synthetic method, comprising the following steps:

1) the 9-fluorenone (10mmol), the phase transfer catalyst (1.5mmol fourteen alkyl trimethyl ammonium chloride) and brominated aqueous ammonium solution (30 wt %, 25mmol ammonium bromide) mixing and heating system temperature to 75 °C, in 1h is divided into three time 11mmol potassium bromate, to three times the weight ratio of 1:3:1, to maintain the system temperature to continue reaction 3h, wherein the 9-fluorenone, ammonium bromide, the molar ratio of potassium bromate 1 : 2.5: 1.1 ; 9-fluorenone, and fourteen alkyl trimethyl ammonium chloride (phase-transfer catalyst) molar ratio of 1 : 0.15; 2) after the reaction, to room temperature, by adding 20% aqueous solution of sodium sulfite ( eliminates the bromine fluid ), is filtered, the filter cake washing water And dried to obtain yellow solid of 2-bromo-9-fluorenone, the yield is 99.2%.

References:

CN104774141,2016,B Location in patent:Paragraph 0032-0036

1133-80-8 Synthesis