2-Chloro-4-ethoxy-1-nitrobenzene synthesis
- Product Name:2-Chloro-4-ethoxy-1-nitrobenzene
- CAS Number:5391-55-9
- Molecular formula:C8H8ClNO3
- Molecular Weight:201.607
Yield:5391-55-9 96%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 40; for 7 h;
Steps:
11.1
Step 1: To a mixture of a (6.9 g, 39.3 mmol, 1.0 eq) and Cs2CO3 (26.0 g, 78.6 mmol, 2.0 eq) in DMF (150.0 mL) was added EtOH (2.7 g, 59.0 mmol, 1.5 eq) at rt. The resulting mixture was stirred at 40 °C for 7 h, cooled to room temperature, diluted with water (500 mL), and then extracted with EtOAc (100 mL x 2). The organic layers were concentrated and the residue purified by chromatography on silica gel (PE/EtOAc=20/1) to afford b (7.6 g, 96.0 %).
References:
WO2020/232375,2020,A1 Location in patent:Page/Page column 109
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