2-CHLORO-5,6-DIMETHYL-3-PYRIDINCARBONITRILE synthesis
- Product Name:2-CHLORO-5,6-DIMETHYL-3-PYRIDINCARBONITRILE
- CAS Number:65176-93-4
- Molecular formula:C8H7ClN2
- Molecular Weight:166.61
72716-80-4
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65176-93-4
39 suppliers
$84.00/200μmol
Yield:65176-93-4 71%
Reaction Conditions:
with trichlorophosphate for 8 h;Heating;
Steps:
5,6-Dimethyl-2-chloro-3-cyanopyridine (III).
Amixture of 1.5 g (0.01 mol) of compound (II) and35 mL of phosphorus oxychloride was heated in aboiling water bath for 8 h. Then the excess of phosphorusoxychloride was distilled off in vacuum, the residuewas alkalized with an aqueous solution of NaOHunder cooling with ice water, the precipitated crystalswere filtered off, washed with water, recrystallizedfrom a CHCl3-EtOH mixture (3 : 1). Yield 71%, mp100-101°C.
References:
Baghdasaryan, M. R.;Dabaeva, V. V.;Dashyan, Sh. Sh.;Hakobyan, H. G.;Hunanyan, L. S.;Nazaryan, I. M.;Paronikyan, E. G.;Paronikyan, R. G. [Russian Journal of Bioorganic Chemistry,2022,vol. 48,# 1,p. 125 - 134][Bioorg. Khim.,2022,vol. 48,# 1,p. 87 - 97]
78-93-3
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107-91-5
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$5.00/10g
109-94-4
495 suppliers
$10.00/10g
65176-93-4
39 suppliers
$84.00/200μmol
72716-80-4
101 suppliers
inquiry
65176-93-4
39 suppliers
$84.00/200μmol