2-Chlorobenzoyl chloride synthesis
- Product Name:2-Chlorobenzoyl chloride
- CAS Number:609-65-4
- Molecular formula:C7H4Cl2O
- Molecular Weight:175.01
118-91-2
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609-65-4
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Yield:609-65-4 100%
Reaction Conditions:
with thionyl chloride in toluene at 75;
Steps:
1
Into a 500 mL round bottom flask was placed a solution of 2-chlorobenzoic acid (20 g, 127.80 mmol) in toluene (150 mL). To the mixture was added SOCl2 (16 g, 134.45 mmol). The resulting solution was allowed to react, with stirring, overnight while the temperature was maintained at 75 0C in a bath of oil. The mixture was concentrated by evaporation under vacuum using a rotary evaporator. This resulted in 22.3 g (100%) of 2-chlorobenzoyl chloride as yellow oil.
References:
MEMORY PHARMACEUTICALS CORPORATION WO2007/98418, 2007, A1 Location in patent:Page/Page column 113-114
79-37-8
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$17.67/10gm:
118-91-2
628 suppliers
$8.50/5g
609-65-4
329 suppliers
$19.00/25mL
89-98-5
622 suppliers
$18.00/25g
609-65-4
329 suppliers
$19.00/25mL