2-CYANO-N-PHENETHYL-ACETAMIDE synthesis
- Product Name:2-CYANO-N-PHENETHYL-ACETAMIDE
- CAS Number:51838-02-9
- Molecular formula:C11H12N2O
- Molecular Weight:188.23
Yield:51838-02-9 42%
Reaction Conditions:
at 100; for 9 h;
Steps:
4.2.2.2. Method B
General procedure: Ethyl cyanoacetate (1 mmol) and the appropriateamine (aniline, benzylamine or (2-bromoethyl)benzene; 1.5 mmol) weremixed and heated at 100 or 150 C for 9-15 h. Cooling gave a solidwhich was purified by flash column chromatography (silica gel) and/orrecrystallization. The procedure was adapted from Roifman et al., 2006[52] with some modifications.
References:
Chavarria, Daniel;Benfeito, Sofia;Soares, Pedro;Lima, Carla;Garrido, Jorge;Serr?o, Paula;Soares-da-Silva, Patrício;Remi?o, Fernando;Oliveira, Paulo J.;Borges, Fernanda [European Journal of Medicinal Chemistry,2022,vol. 243,art. no. 114740]
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