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(2-Bromoethyl)benzene

(2-Bromoethyl)benzene Structure
(2-Bromoethyl)benzene structure
CAS No.
103-63-9
Chemical Name:
(2-Bromoethyl)benzene
Synonyms
PHENETHYL BROMIDE;2-Phenethyl bromide;2-PHENYLETHYL BROMIDE;1-BROMO-2-PHENYLETHANE;Benzene, (2-bromoethyl)-;1-phenyl-2-bromoethane;Tetrabomoethane;β - Bromobenzene;2-phenethylbromide;-Bromoethylbenzene
CBNumber:
CB0427485
Molecular Formula:
C8H9Br
Molecular Weight:
185.06
MDL Number:
MFCD00000240
MOL File:
103-63-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-10 10:27:01
Product description Number Pack Size Price
(2-Bromoethyl)benzene 98% B65780 5g $47.5
Fentanyl Related Compound A United States Pharmacopeia (USP) Reference Standard 1269913 100mg $1390
(2-Bromoethyl)benzene B0594 100G $38
(2-Bromoethyl)benzene B0594 500G $98
Phenethylbromide ≥98% 20087 1mg $22
More product size
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(2-Bromoethyl)benzene Properties

Melting point -56 °C
Boiling point 220-221 °C(lit.)
Density 1.355 g/mL at 25 °C(lit.)
refractive index n20/D 1.556(lit.)
Flash point 193 °F
storage temp. 2-8°C
solubility 0.039g/l
form Liquid
color Clear colorless to pale yellow
Water Solubility INSOLUBLE
BRN 507487
Henry's Law Constant 6.5×10-3 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
Stability Stable. Incompatible with strong oxidizing agents.
InChI 1S/C8H9Br/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2
InChIKey WMPPDTMATNBGJN-UHFFFAOYSA-N
SMILES BrCCc1ccccc1
CAS DataBase Reference 103-63-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 96O442668X
NIST Chemistry Reference 1-Bromo-2-phenylethane(103-63-9)
EPA Substance Registry System Benzene, (2-bromoethyl)- (103-63-9)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P301+P312+P330-P305+P351+P338
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-36-36/37/38
Safety Statements  26-37/39-39
RIDADR  UN 1993 / PGIII
WGK Germany  3
RTECS  CY9032000
TSCA  TSCA listed
HS Code  29036990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Hazardous Substances Data 103-63-9(Hazardous Substances Data)
NFPA 704
2
1 0

(2-Bromoethyl)benzene price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B65780 (2-Bromoethyl)benzene 98% 103-63-9 5g $47.5 2026-04-30 Buy
Sigma-Aldrich 1269913 Fentanyl Related Compound A United States Pharmacopeia (USP) Reference Standard 103-63-9 100mg $1390 2026-04-30 Buy
TCI Chemical B0594 (2-Bromoethyl)benzene 103-63-9 100G $38 2026-04-30 Buy
TCI Chemical B0594 (2-Bromoethyl)benzene 103-63-9 500G $98 2026-04-30 Buy
Cayman Chemical 20087 Phenethylbromide ≥98% 103-63-9 1mg $22 2026-04-30 Buy
Product number Packaging Price Buy
B65780 5g $47.5 Buy
1269913 100mg $1390 Buy
B0594 100G $38 Buy
B0594 500G $98 Buy
20087 1mg $22 Buy

(2-Bromoethyl)benzene Chemical Properties,Uses,Production

Description

Phenethylbromide is an analytical reference material that is structurally categorized as an organobromide. It is used in the synthesis of a variety of compounds, including fentanyl. Phenethylbromide is combined with 4-piperidinone to produce N-phenethyl-4-piperidone, which, as a precursor in the synthesis of fentanyl, is scheduled as a List I chemical in the United States. Phenethylbromide may be found as in impurity in samples of fentanyl produced using this pathway.

Chemical Properties

colourless to yellow liquid. It is miscible with ether and benzene, but insoluble in water.

Uses

(2-Bromoethyl)benzene is used in the preparation of phenelzine by reacting with hydrazine. It is also used as a starting material to prepare various beta-phenethyl derivatives, active pharmaceutical ingredients, and fragrances. It finds application as a flame retardant.

Uses

(2-Bromoethyl)benzene is an important starting material for the production of various b-phenethyl derivatives, pharmaceuticals, fragrances, and other fine chemicals.

Preparation

(2-Bromoethyl)benzene is synthesized by the reaction of phenethyl alcohol with hydrogen bromide.
Reaction: The phenethyl alcohol was heated to 110°C, hydrogen bromide was slowly introduced, and the reaction was refluxed. The reaction was completed, cooled, washed with water, 10% sodium carbonate solution, and water in turn. After drying with anhydrous potassium carbonate, fractional distillation under reduced pressure was carried out to collect fractions at 97-99°C (2.0 kPa) with a yield of over 90%.

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 2317, 1964 DOI: 10.1021/jo01031a051
Synthetic Communications, 20, p. 2349, 1990 DOI: 10.1080/00397919008053179

Safety

Store at 2-8° C in a tightly closed container in a dry, well-ventilated place. Containers that are opened must be carefully resealed and kept upright to prevent leakage. (2-Bromoethyl)benzene is incompatible with strong oxidizing agents. This chemical is harmful if swallowed and causes severe eye irritation.

Synthesis

Phenethylbromide is commonly synthesized through the addition of HBr to styrene via a free-radical reaction. This process is typically carried out in a glasslined reactor by introducing gaseous HBr into a solution of styrene in an inert solvent that contains a free-radical initiator. The reaction, which is fast and releases a moderate amount of heat, can be managed by introducing HBr at a rate that matches its consumption. Once all the styrene has been converted, any remaining excess HBr can be reclaimed using different methods before the solvent and product are recovered through distillation.

Purification Methods

Wash the bromide with conc H2SO4, water, aqueous 10% Na2CO3 and water again, then dry it with CaCl2 and fractionally distil it just before use. [Beilstein 5 IV 907.]

Toxics Screening Level

The Initial Threshold Screening Level (ITSL) is 2.7 μg/m3 with an annual averaging time.

References

1. Shukla, P.; Sharma, A.; Pallavi, B.; Cheng, C. H. Nickel-catalyzed reductive Heck type coupling of saturated alkyl halides with acrylates and oxabenzonorbornadiene. Tetrahedron 2015, 71 (15), 2260-2266. DOI:10.1016/J.TET.2015.02.067
2. Huang, Y. B.; Yan, L.; Chen, M. Y.; Guo, Q. X.; Fu, Y. Selective hydrogenolysis of phenols and phenyl ethers to arenes through direct C-O cleavage over ruthenium-tungsten bifunctional catalysts. Green Chem. 2015, 17 (5), 3010-3017. DOI:10.1039/C5GC00326A
3. Justice, D.E.A.D.o. Control of a chemical precursor used in the illicit manufacture of fentanyl as a List I chemical. Final rule. Federal Register 73(144), 43355-43357 (2008). PMID: 18949877

(2-Bromoethyl)benzene synthesis

60-12-8
103-63-9
Synthesis of (2-Bromoethyl)benzene from Phenethyl alcohol

(2-Bromoethyl)benzene Preparation Products And Raw materials

Raw materials

Potassium carbonate Phenethyl alcohol

Preparation Products

1-Phenyl-1,2-ethanediol 1-(2-PHENYLETHYL)PIPERAZINE 4-Vinylbenzyl chloride N-METHYLPHENETHYLAMINE Carfentanil
Benzene, [dimethyl(2-phenylethyl)silyl]- 5-PHENYL-N-VALERIC ACID METHYL ESTER diethyl 2-acetamido-2-phenethyl-propanedioate 2-PHENYLETHYL-1-BORONIC ACID PINACOL ESTER 1-(PHENYL) 2-NITROETHANE
2-PHENYLETHYL PHENYL ETHER 4-(2-BROMOETHYL)BENZOIC ACID CENTIFOLYL 1,4-DIPHENYLBUTANE 1-Bromo-4-phenylbutane
2-PHENYLETHYL PROPIONATE 1,2-Ethanediyl, 1-phenyl- (9CI)

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(2-Bromoethyl)benzene Suppliers

Global( 554)Suppliers
Supplier Tel Email Country ProdList Advantage
Guangzhou Xijia New Materials Co.,Ltd 		+undefined13650882421 ebswax@163.com China 54 58
Shijiazhuang Gantuo Biotechnology Co., Ltd
+8613373514458 gantuo02@cngantuo.com China 203 58
LY Global chemicals co.,ltd .
+8618939937369 info@lychems.cn China 969 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677 faithe@yan-xi.com China 5853 58
Shijiazhuang Jianxin Biotechnology Co., LTD
+undefined-86-1906231316-9 +undefined86-19062313169 liyingjian1997@gmail.com China 712 58
Yancheng Longshen Chemical Co.,Ltd. 		+86-18352073383 +86-18352073383 sales@longshenchem.com China 100 55
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3590 58
Hubei Aumei New Material Co., Ltd. 		+86-027-87366298 +8615927270571 tianyi@skbiology.cn China 282 58
Hebei Dangtong Import and export Co LTD 		+86-86-4001020630 +8619831957301 admin@hbdangtong.com China 1000 58
Firsky International Trade (Wuhan) Co., Ltd 		+8615387054039 admin@firsky-cn.com China 427 58
Supplier Advantage
Guangzhou Xijia New Materials Co.,Ltd 		58
Shijiazhuang Gantuo Biotechnology Co., Ltd
58
LY Global chemicals co.,ltd .
58
Hebei Yanxi Chemical Co., Ltd.
58
Shijiazhuang Jianxin Biotechnology Co., LTD
58
Yancheng Longshen Chemical Co.,Ltd. 		55
Shaanxi Dideu Medichem Co. Ltd 		58
Hubei Aumei New Material Co., Ltd. 		58
Hebei Dangtong Import and export Co LTD 		58
Firsky International Trade (Wuhan) Co., Ltd 		58

Related articles

Related Qustion

Ask a question
Q:What are the functions and harms of (2-Bromoethyl)benzene?Zora - Mar 10，2026
A:(2-Bromoethyl)benzene is a brominated ethylbenzene compound for proteomics research. It is believed to interact with various receptor sites in the body. Specifically, it is thought to interact with the serotonin, dopamine, and norepinephrine receptor sites. It is also believed to interact with the GABA receptor, which is involved in the regulation of the nervous system. (2-Bromoethyl)benzene is a flammable liquids, it has acute oral toxicity and serious eye damage/eye irritation.

View Lastest Price from (2-Bromoethyl)benzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2-Bromoethyl)benzene; 2-Phenylethyl bromide; β-Bromoethylbenzene pictures 2026-04-30 (2-Bromoethyl)benzene; 2-Phenylethyl bromide; β-Bromoethylbenzene
103-63-9
 US $0.00 / KG 1KG ≥98.5% 80 Tons/Month Yancheng Longshen Chemical Co.,Ltd.
(2-Bromoethyl)benzene pictures 2026-04-30 (2-Bromoethyl)benzene
103-63-9
 US $999.00-666.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
(2-Bromoethyl)benzene pictures 2026-04-30 (2-Bromoethyl)benzene
103-63-9
 US $1000.00-800.00 / kg 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

(2-Bromoethyl)benzene Spectrum

(2-Bromoethyl)benzene(103-63-9)MS(2-Bromoethyl)benzene(103-63-9)1HNMR(2-Bromoethyl)benzene(103-63-9)13CNMR(2-Bromoethyl)benzene(103-63-9)IR1(2-Bromoethyl)benzene(103-63-9)IR2(2-Bromoethyl)benzene(103-63-9)Raman

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