2-CYANO-N-PROPYLACETAMIDE synthesis
- Product Name:2-CYANO-N-PROPYLACETAMIDE
- CAS Number:52493-35-3
- Molecular formula:C6H10N2O
- Molecular Weight:126.16
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Yield:52493-35-3 98%
Reaction Conditions:
at 20;
Steps:
65.1
Step 1. 2-Cyano-N-propylacetamide A solution of ethyl 2-cyanoacetate (10 g, 88.5 mmol) in propan-1-amine (30 ml) was stirred overnight at room temperature and then concentrated in vacuo. The solid was precipitated from water (50 mL) and collected by filtration to afford 2-cyano-N-propylacetamide as a white solid (11 g, 98%). LC/MS (ES, m/z): [M+H]+. 127.1 1H-NMR (300 MHz, CDCl3) δ 6.16 (s, 1H), 3.47 (s, 2H), 3.26-3.39 (m, 2H), 1.53-1.66 (m, 2H), 0.94-0.99 (t, J=7.5 Hz, 3H)
References:
US2012/277224,2012,A1 Location in patent:Page/Page column 53
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