2-Fluoropyridine-5-boronic acid pinacol ester synthesis
- Product Name:2-Fluoropyridine-5-boronic acid pinacol ester
- CAS Number:444120-95-0
- Molecular formula:C11H15BFNO2
- Molecular Weight:223.05
766-11-0
457 suppliers
$6.00/5g
73183-34-3
593 suppliers
$6.00/5g
444120-95-0
179 suppliers
$6.00/250mg
Yield:444120-95-0 90%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium acetate in 1,4-dioxane;water at 100; for 12 h;Inert atmosphere;
Steps:
1 Synthesis of intermediate E2-1
Add 2-fluoro-5-bromopyridine (17.6g) to a 1000ml three-necked flask, bis(pinacolato)diboron (38.1g),And potassium acetate (50.0g),Pd (PPh3) 4 (5.7g),Add 600/100 ml of Dioxane / H2O solvent and stir at 100 ° C for 12h under a nitrogen atmosphere.After cooling, the filtrate was filtered off with suction, the solvent was spin-dried and extracted with dichloromethane.Column chromatography was then used to obtain intermediate E2-1 in 90% yield.MS (ASAP): 223.05.
References:
CN110759910,2020,A Location in patent:Paragraph 0185-0187
76-09-5
393 suppliers
$10.00/1g
766-11-0
457 suppliers
$6.00/5g
444120-95-0
179 suppliers
$6.00/250mg
76-09-5
393 suppliers
$10.00/1g
171197-80-1
292 suppliers
$20.00/1g
444120-95-0
179 suppliers
$6.00/250mg
1480-65-5
303 suppliers
$7.00/1g
73183-34-3
593 suppliers
$6.00/5g
444120-95-0
179 suppliers
$6.00/250mg
20511-12-0
464 suppliers
$6.00/1g
444120-95-0
179 suppliers
$6.00/250mg