ChemicalBook CAS DataBase List 2-FLUORO-5-METHOXYBENZONITRILE

2-FLUORO-5-METHOXYBENZONITRILE synthesis

5synthesis methods

Product Name:2-FLUORO-5-METHOXYBENZONITRILE
CAS Number:127667-01-0
Molecular formula:C8H6FNO
Molecular Weight:151.14

Benzaldehyde, 2-fluoro-5-methoxy-, oxime

796120-91-7

127667-01-0

The general procedure for the synthesis of 2-fluoro-5-methoxybenzonitrile from the compound (CAS: 796120-91-7) was as follows: 15 g of 2-fluoro-5-methoxybenzaldehyde oxime was dissolved in 150 mL of tetrahydrofuran, followed by the addition of 40 g of trifluoroacetic anhydride. 20 mL of triethylamine was slowly added under stirring. Upon completion of the reaction, the reaction mixture was concentrated to remove the solvent. Water was added to the concentrate and extracted with ethyl acetate. The organic phase was separated, dried with anhydrous sodium sulfate, and then concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography to give 11 g of 2-fluoro-5-methoxybenzonitrile.

796120-91-7
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127667-01-0
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Yield: 11 g

Reaction Conditions:

with triethylamine;trifluoroacetic anhydride in tetrahydrofuran

Steps:

1.3 (3) Synthesis of 2-Fluoro-5-methoxybenzonitrile
15 g of 2-fluoro-5-methoxybenzaldehyde oxime was added to 150 ml of tetrahydrofuran,Add 40g of trifluoroacetic anhydride,Then add 20ml triethylamine,concentrate,Add water and ethyl acetate to extract,Collect the organic phase,dry,concentrate,The residue was separated on a silica gel column to give 11 g of 2-fluoro-5-methoxybenzonitrile.

References:

Hunan Huateng Pharmaceutical Co., Ltd.;Bu Gonggaofamingren CN107778264, 2018, A Location in patent:Paragraph 0029; 0030

67-56-1 Synthesis