2-Hydroxy-N-(2-hydroxyethyl)acetamide synthesis
- Product Name:2-Hydroxy-N-(2-hydroxyethyl)acetamide
- CAS Number:3586-25-2
- Molecular formula:C4H9NO3
- Molecular Weight:119.12
75-77-4
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Yield:3586-25-2 74.4 mg
Reaction Conditions:
Stage #1: chloro-trimethyl-silane;ethanolaminewith triethylamine in dichloromethane at 20; for 0.5 h;Inert atmosphere;
Stage #2: Acetoxyacetyl chloride in dichloromethane at 20; for 19 h;Inert atmosphere;Cooling with ice;
Stage #3: with potassium carbonate in methanol at 20; for 4 h;Inert atmosphere;
References:
Nishikawa, Yasuhiro;Takemoto, Kohei;Matsuda, Kana;Tanaka, Risa;Arashima, Akira;Ito, Kanako;Kamezawa, Yuki;Hori, Yuna;Hara, Osamu [Organic Letters,2018,vol. 20,# 11,p. 3367 - 3371] Location in patent:supporting information
