2-METHOXY-6-METHYLBENZOIC ACID ETHYL ESTER synthesis
- Product Name:2-METHOXY-6-METHYLBENZOIC ACID ETHYL ESTER
- CAS Number:6520-83-8
- Molecular formula:C11H14O3
- Molecular Weight:194.23
6555-40-4
74-88-4
6520-83-8
Ethyl 2-hydroxy-6-methylbenzoate (1.0 g, 5.6 mmol), iodomethane (866 mg, 6.1 mmol), and potassium carbonate (1.5 g, 11.1 mmol) were dissolved in acetone (20 mL) and the reaction was heated to reflux for 17 hours. Upon completion of the reaction, the reaction was quenched by adding water (20 mL) to the reaction mixture and extracted with dichloromethane (3 × 20 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: 100% hexane) to afford ethyl 2-methoxy-6-methylbenzoate (1.1 g, 99% yield) as a colorless oil.
6555-40-4
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77-78-1
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$19.69/1ml
6520-83-8
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$45.00/1g
Yield: 96%
Reaction Conditions:
with potassium carbonate in acetoneHeating;
References:
Hauser, Frank M.;Pogany, Stefano A. [Synthesis,1980,# 10,p. 814 - 815]
6555-40-4
165 suppliers
$30.00/1 g
74-88-4
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$15.00/10g
6520-83-8
127 suppliers
$45.00/1g
6555-40-4
165 suppliers
$30.00/1 g
6520-83-8
127 suppliers
$45.00/1g