2-(METHYLSULFONYL)ETHANOL synthesis
- Product Name:2-(METHYLSULFONYL)ETHANOL
- CAS Number:15205-66-0
- Molecular formula:C3H8O3S
- Molecular Weight:124.16
2-(Methylsulfonyl)ethanol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development process. Its synthesis method is as follows：Epoxyethane, methanesulfonyl chloride with zinc in ethanol was heated for 0.25 h and the reaction solution was purified to give 2-(Methylsulfonyl)ethanol.
5271-38-5
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15205-66-0
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Yield:15205-66-0 97%
Reaction Conditions:
with dihydrogen peroxide;3H(1+)*(PW12O40)(3-) in water at 20; for 0.5 h;
Steps:
2.4.2. General procedure for the oxidation of sulfides
General procedure: A mixture of the PW12 nanoflower (10 mg) as catalyst, 30% H2O2 aqueous solution(100 mL) and solvent (600 mL) was placed in a 10mL glass bottle. After 5 min, the substrate(1 mmol) was added under stirring. The reaction time was counted after theaddition of sulfide, and then the reaction mixture was stirred at the experiment temperaturefor the appropriate time. The sample was collected from the mixture at timeintervals and then the progress of the reaction was followed by TLC (eluent: n-hexane/EtOAc, 3:1) and stopped when complete conversion of the substrate wasobserved. The catalyst was filtered off at the end of reactions, washed several timeswith ethyl acetate followed by ethanol (45 mL), heated in an oven at 70 °C overnightand then reused using the same reaction conditions. The starting material andproduct are insoluble in water and it was used just as an environment for stirring.Therefore, the reaction mixture was transferred to a separating funnel and the productwas extracted with CH2Cl2 (35 mL). After evaporation of organic layer, the crudeproducts were recrystallized from hot ethanol and the pure products were obtained in94-98% yield. Recovering of the PW12 nanoflower catalyst was carried out in four consecutiveexperiments.
References:
Pirdosti, Soleiman Fazeli;Khoshnavazi, Roushan;Naseri, Elham [Journal of Coordination Chemistry,2020,vol. 73,# 5,p. 723 - 736]
75-21-8
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124-63-0
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15205-66-0
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15205-66-0
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64-19-7
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