2-(METHYLTHIO)-2-THIAZOLINE synthesis
- Product Name:2-(METHYLTHIO)-2-THIAZOLINE
- CAS Number:19975-56-5
- Molecular formula:C4H7NS2
- Molecular Weight:133.24
134469-06-0
74-88-4
19975-56-5
General procedure for the synthesis of 2-methylthio-2-thiazoline from thiazolidine-2-thione and iodomethane: Thiazolidine-2-thione (2 g, 0.0168 mol) was dissolved in acetonitrile (20 ml) and iodomethane (1.04 ml, 0.0168 mol) was added. The reaction mixture was heated to reflux for 3 hours and subsequently cooled to room temperature. The reaction mixture was filtered and the white solid obtained was collected. The solid was poured into saturated potassium carbonate solution (20 ml) to form an oil. The oily substance was extracted with dichloromethane and the organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a colorless liquid product (1.4 g, 63% yield).
Yield: 88%
Reaction Conditions:
in acetone for 3 h;Heating;
References:
Singh, Kamal Nain;Singh, Paramjit;Kaur, Amarjit [Synthetic Communications,2006,vol. 36,# 22,p. 3339 - 3343]
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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