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Trimethyloxonium Tetrafluoroborate

CAS No.
420-37-1
Chemical Name:
Trimethyloxonium Tetrafluoroborate
Synonyms
TriMethyloxoniuM Fluoroborate;triMethyloxoiuM tetrafluoroborate;trimethyl-oxoniu tetrafluoroborate;SKL1456;SKL1563;NSC 528455;oxonium tetrafL;trimethyloxidanium;Oxonium, trimethyl-;Trimethoxonium fluoroborate
CBNumber:
CB3184284
Molecular Formula:
C3H9BF4O
Molecular Weight:
147.91
MDL Number:
MFCD00011798
MOL File:
420-37-1.mol
MSDS File:
SDS
Last updated:2024-08-01 09:07:02

Trimethyloxonium Tetrafluoroborate Properties

Melting point 200 °C
storage temp. Store at +2°C to +8°C.
solubility Soluble in nitrobenzene, nitromethane, chloroform, hot acetone, liquid sulfur dioxide. Slightly soluble in dichloromethane. Insoluble in common organic solvents.
form Crystals
color White to off-white
Sensitive Moisture Sensitive
BRN 3597303
InChI InChI=1S/C3H9O.BF4/c1-4(2)3;2-1(3,4)5/h1-3H3;/q+1;-1
InChIKey JDFKFXJJAIJXPP-UHFFFAOYSA-M
SMILES [B-](F)(F)(F)F.[O+](C)(C)C
CAS DataBase Reference 420-37-1(CAS DataBase Reference)
FDA UNII BFC3NMU8S8
EPA Substance Registry System Oxonium, trimethyl-, tetrafluoroborate(1-) (420-37-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C
Risk Statements  14-34
Safety Statements  26-36/37/39-43-45
RIDADR  UN 3261 8/PG 2
WGK Germany  3
3-10-21
Hazard Note  Corrosive/Freeze
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29420000
NFPA 704
1
3 2
W

Trimethyloxonium Tetrafluoroborate price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 281077 Trimethyloxonium tetrafluoroborate 95% 420-37-1 1g $39.6 2024-03-01 Buy
Sigma-Aldrich 281077 Trimethyloxonium tetrafluoroborate 95% 420-37-1 10g $82.7 2024-03-01 Buy
TCI Chemical T1507 Trimethyloxonium Tetrafluoroborate >95.0%(T) 420-37-1 5g $37 2024-03-01 Buy
TCI Chemical T1507 Trimethyloxonium Tetrafluoroborate >95.0%(T) 420-37-1 25g $98 2024-03-01 Buy
Alfa Aesar A15175 Trimethyloxonium tetrafluoroborate 96% 420-37-1 10g $75 2024-03-01 Buy
Product number Packaging Price Buy
281077 1g $39.6 Buy
281077 10g $82.7 Buy
T1507 5g $37 Buy
T1507 25g $98 Buy
A15175 10g $75 Buy

Trimethyloxonium Tetrafluoroborate Chemical Properties,Uses,Production

Description

Trimethyloxonium tetrafluoroborate (TMO), a trialkyloxonium salt, is a white salt at ambient temperature that can be added directly to reaction media to carry out the methylation of reactive, acidic analytes. The main drawback associated with the employment of TMO is the generation of tetrafluoroboric acid (HBF4), which may interfere with the analysis of acid-sensitive analytes and cause column degradation over time. However, the effects of this acid can be countered by neutralization with inorganic bases like sodium or potassium bicarbonate during the sample preparation step before instrument injection. This approach has proven crucially useful in analysing phosphonic and sulfonic acids related to organophosphorus-based nerve agents. TMO could be employed as a derivatizing agent in the methylation of a panel of environmentally relevant chlorinated phenols. It is also used in neutral and basic solutions for the selective methylation of the carboxyl groups of protohemin IX, hematohemin, and heme a[1-2].

Chemical Properties

This substance is a white to off-white crystals that is prone to water sensitivity and displays a level of hygroscopicity.

Uses

Trimethyloxonium Tetrafluoroborate is a trialkylated oxonium used as a methylation agent in organic synthesis. It is a reagent for the methylation of hydroxyl groups recently used in a complex, multistep synthesis directed towards spirastrellolide, a marine natural product.

Uses

Trimethyloxonium tetrafluoroborate act as a avmethylating agent and activates C-X multiple bonds. It is involved in the esterification of polyfunctional carboxylic acids. It acts as a catalyst in the polymerization of cyclic sulfides and ethers. Further, it is used in Beckmann rearrangement of oximes.

Health Hazard

Trimethyloxonium Tetrafluoroborate is a potent alkylating agent, with its non-volatile nature reducing associated hazards. Nevertheless, it produces strong acids upon contact with water, so it is important to exercise caution and prevent water contact during its application.

References

[1] Carlos A Valdez, Roald N Leif, Edmund P Salazar. “Trimethyloxonium-mediated methylation strategies for the rapid and simultaneous analysis of chlorinated phenols in various soils by electron impact gas chromatography-mass spectrometry.” Scientific Reports (2022): 1401.
[2] R T Dean, D E Hultquist, L J DeFilippi. “Esterification of hemins with trimethyloxonium tetrafluoroborate.” Analytical biochemistry 76 l (1976): 1–8.

115-10-6
109-63-7
420-37-1
Synthesis of Trimethyloxonium Tetrafluoroborate from Dimethyl ether and Boron trifluoride diethyl etherate
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View Lastest Price from Trimethyloxonium Tetrafluoroborate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trimethyloxonium Tetrafluoroborate pictures 2024-08-27 Trimethyloxonium Tetrafluoroborate
420-37-1
US $0.00-0.00 / KG 100KG 99.9% 20TONS Zibo Hangyu Biotechnology Development Co., Ltd
METHYLOXONIUM TETRAFLUOROBORATE pictures 2024-02-26 METHYLOXONIUM TETRAFLUOROBORATE
420-37-1
US $0.00-0.00 / kg 1kg 98% Kgs BTC Nantong Pharmaceuticals Technology Co.,Ltd
Trimethyloxonium Tetrafluoroborate pictures 2023-09-11 Trimethyloxonium Tetrafluoroborate
420-37-1
US $50.00 / kg 1kg 99% 10000tons Anhui Ruihan Technology Co., Ltd
TRIMETHYLOXONIUM TETRAFLUOROBORATE trimethyl-oxoniutetrafluoroborate(1-) trimethyloxonium tetrafluoroborate(1-) Trimethyloxonium tetrafluoroborate 98+% Trimethyloxoniumtetrafluoroborate,C24%min Trimethyloxonium tetrafluoroborate 98% Trimethyloxoniumtetrafluoroborate,min.95% Oxonium, trimethyl-, tetrafluoroborate(1-) Trimethyloxonium tetrafluoroborate, 97+% Trimethyloxonium tetrafluoroborate, min. 95% Trimethyloxonium tetrafluoroborate,95% Oxonium, trimethyl- TriMethyloxoniuM tetrafluorobo TriMethyloxoniuM tetrafluoroborate, 95% 10GR NSC 528455 trimethyloxidanium SKL1456 SKL1563 TRIMETHYLOXONIUM TETRAFLUOROBORATE FOR S Trimethoxonium fluoroborate96% oxonium tetrafL trimethyl-oxoniu tetrafluoroborate TriMethyloxoniuM Fluoroborate triMethyloxoiuM tetrafluoroborate METHYLOXONIUM TETRAFLUOROBORATE Trimethoxynium tetrafluoroborate TRIMETHYLOXONIUM TETRAFLUOROBORATE [Me3O]BF4 Trimethyloxonium tetrafluoroborate (7CI) Trimethoxonium fluoroborate Trimethyloxonium Tetrafluroborate 420-37-1 420-37-0 CH33OBF4 C3H9BF4O C3H9OBF4 Tetrafluoroborates B (Classes of Boron Compounds) Oxonium Compounds Iodonium Sulfonium & Oxonium Compounds Alkyl Transfer Synthetic Reagents C-X Bond Formation (Non-Halogen) halometallate salts B (Classes of Boron Compounds) Iodonium Sulfonium & Oxonium Compounds Oxonium Compounds Tetrafluoroborates Alkyl Transfer C-X Bond Formation (Non-Halogen) Synthetic Reagents