Trimethyloxonium Tetrafluoroborate
- CAS No.
- 420-37-1
- Chemical Name:
- Trimethyloxonium Tetrafluoroborate
- Synonyms
- TriMethyloxoniuM Fluoroborate;triMethyloxoiuM tetrafluoroborate;trimethyl-oxoniu tetrafluoroborate;SKL1456;SKL1563;NSC 528455;oxonium tetrafL;trimethyloxidanium;Oxonium, trimethyl-;Trimethoxonium fluoroborate
- CBNumber:
- CB3184284
- Molecular Formula:
- C3H9BF4O
- Molecular Weight:
- 147.91
- MDL Number:
- MFCD00011798
- MOL File:
- 420-37-1.mol
- MSDS File:
- SDS
| Melting point | 200 °C |
|---|---|
| storage temp. | Store at +2°C to +8°C. |
| solubility | Soluble in nitrobenzene, nitromethane, chloroform, hot acetone, liquid sulfur dioxide. Slightly soluble in dichloromethane. Insoluble in common organic solvents. |
| form | Crystals |
| color | White to off-white |
| Sensitive | Moisture Sensitive |
| BRN | 3597303 |
| InChI | InChI=1S/C3H9O.BF4/c1-4(2)3;2-1(3,4)5/h1-3H3;/q+1;-1 |
| InChIKey | JDFKFXJJAIJXPP-UHFFFAOYSA-M |
| SMILES | [B-](F)(F)(F)F.[O+](C)(C)C |
| CAS DataBase Reference | 420-37-1(CAS DataBase Reference) |
| FDA UNII | BFC3NMU8S8 |
| EPA Substance Registry System | Oxonium, trimethyl-, tetrafluoroborate(1-) (420-37-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 14-34 | |||||||||
| Safety Statements | 26-36/37/39-43-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-21 | |||||||||
| Hazard Note | Corrosive/Freeze | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29420000 | |||||||||
| NFPA 704 |
|
Trimethyloxonium Tetrafluoroborate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 281077 | Trimethyloxonium tetrafluoroborate 95% | 420-37-1 | 1g | $39.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 281077 | Trimethyloxonium tetrafluoroborate 95% | 420-37-1 | 10g | $82.7 | 2024-03-01 | Buy |
| TCI Chemical | T1507 | Trimethyloxonium Tetrafluoroborate >95.0%(T) | 420-37-1 | 5g | $37 | 2024-03-01 | Buy |
| TCI Chemical | T1507 | Trimethyloxonium Tetrafluoroborate >95.0%(T) | 420-37-1 | 25g | $98 | 2024-03-01 | Buy |
| Alfa Aesar | A15175 | Trimethyloxonium tetrafluoroborate 96% | 420-37-1 | 10g | $75 | 2024-03-01 | Buy |
Trimethyloxonium Tetrafluoroborate Chemical Properties,Uses,Production
Description
Trimethyloxonium tetrafluoroborate (TMO), a trialkyloxonium salt, is a white salt at ambient temperature that can be added directly to reaction media to carry out the methylation of reactive, acidic analytes. The main drawback associated with the employment of TMO is the generation of tetrafluoroboric acid (HBF4), which may interfere with the analysis of acid-sensitive analytes and cause column degradation over time. However, the effects of this acid can be countered by neutralization with inorganic bases like sodium or potassium bicarbonate during the sample preparation step before instrument injection. This approach has proven crucially useful in analysing phosphonic and sulfonic acids related to organophosphorus-based nerve agents. TMO could be employed as a derivatizing agent in the methylation of a panel of environmentally relevant chlorinated phenols. It is also used in neutral and basic solutions for the selective methylation of the carboxyl groups of protohemin IX, hematohemin, and heme a[1-2].
Chemical Properties
This substance is a white to off-white crystals that is prone to water sensitivity and displays a level of hygroscopicity.
Uses
Trimethyloxonium Tetrafluoroborate is a trialkylated oxonium used as a methylation agent in organic synthesis. It is a reagent for the methylation of hydroxyl groups recently used in a complex, multistep synthesis directed towards spirastrellolide, a marine natural product.
Uses
Trimethyloxonium tetrafluoroborate act as a avmethylating agent and activates C-X multiple bonds. It is involved in the esterification of polyfunctional carboxylic acids. It acts as a catalyst in the polymerization of cyclic sulfides and ethers. Further, it is used in Beckmann rearrangement of oximes.
Health Hazard
Trimethyloxonium Tetrafluoroborate is a potent alkylating agent, with its non-volatile nature reducing associated hazards. Nevertheless, it produces strong acids upon contact with water, so it is important to exercise caution and prevent water contact during its application.
References
[1] Carlos A Valdez, Roald N Leif, Edmund P Salazar. “Trimethyloxonium-mediated methylation strategies for the rapid and simultaneous analysis of chlorinated phenols in various soils by electron impact gas chromatography-mass spectrometry.” Scientific Reports (2022): 1401.
[2] R T Dean, D E Hultquist, L J DeFilippi. “Esterification of hemins with trimethyloxonium tetrafluoroborate.” Analytical biochemistry 76 l (1976): 1–8.
Trimethyloxonium Tetrafluoroborate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18629 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
View Lastest Price from Trimethyloxonium Tetrafluoroborate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-27 | Trimethyloxonium Tetrafluoroborate
420-37-1
|
US $0.00-0.00 / KG | 100KG | 99.9% | 20TONS | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2024-02-26 | METHYLOXONIUM TETRAFLUOROBORATE
420-37-1
|
US $0.00-0.00 / kg | 1kg | 98% | Kgs | BTC Nantong Pharmaceuticals Technology Co.,Ltd | |
 |
2023-09-11 | Trimethyloxonium Tetrafluoroborate
420-37-1
|
US $50.00 / kg | 1kg | 99% | 10000tons | Anhui Ruihan Technology Co., Ltd |
-
- Trimethyloxonium Tetrafluoroborate
420-37-1
- US $0.00-0.00 / KG
- 99.9%
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- METHYLOXONIUM TETRAFLUOROBORATE
420-37-1
- US $0.00-0.00 / kg
- 98%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
-
- Trimethyloxonium Tetrafluoroborate
420-37-1
- US $50.00 / kg
- 99%
- Anhui Ruihan Technology Co., Ltd
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