2-Propenenitrile,3-(3-fluorophenyl)-,(E)-(9CI) synthesis

5synthesis methods

Product Name:2-Propenenitrile,3-(3-fluorophenyl)-,(E)-(9CI)
CAS Number:82344-56-7
Molecular formula:C9H6FN
Molecular Weight:147.15

456-47-3 Synthesis

456-47-3
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75-05-8 Synthesis

75-05-8
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2-Propenenitrile,3-(3-fluorophenyl)-,(E)-(9CI)

82344-56-7
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Yield:82344-56-7 85%

Reaction Conditions:

with iron(III) oxide;caesium carbonate at 87; for 8 h;

Steps:

6

A process for the preparation of trans-α, β-unsaturated nitrile compounds, which means that 3-fluorobenzeneMethanol, acetonitrile, ferric oxide and cesium carbonate were mixed uniformly and reacted at 87 ° C for 8 hours.Wherein the molar ratio of 3-fluorobenzyl alcohol to ferric oxide is 1: 1; the molar ratio of 3-fluorobenzyl alcohol to cesium carbonate is5: 3; the molar ratio of 3-fluorobenzyl alcohol to acetonitrile is 1: 120.[0032] The reaction was followed by the thin layer chromatography as described in Example 1; the reaction was carried out as described in Example 1(E) -3- (3-fluorophenyl) acrylonitrile in the order of 85% by extraction, drying, concentration and column chromatography.

References:

CN106588696,2017,A Location in patent:Paragraph 0030-0032