ChemicalBook CAS DataBase List 3-Fluorobenzaldehyde

3-Fluorobenzaldehyde synthesis

14synthesis methods

Product Name:3-Fluorobenzaldehyde
CAS Number:456-48-4
Molecular formula:C7H5FO
Molecular Weight:124.11

456-47-3 Synthesis

456-47-3
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$10.00/1g

456-48-4
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$9.00/25g

Yield:456-48-4 95%

Reaction Conditions:

with dmap;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;copper(I) triflate;5-[(2S)-pyrrolidine-2-yl]-1H-tetrazole in acetonitrile at 25; for 1.5 h;Catalytic behavior;chemoselective reaction;

Steps:

4 4.1.2. The oxidation of primary alcohols

General procedure: A round-bottom flask was charged with alcohol (2 mmol), CuOTf (0.1 mmol, 0.05 equiv) (S)-5-(pyrrolidin-2-yl)-1H-tetrazole (0.1 mmol, 0.05 equiv), TEMPO (0.1 mmol, 0.05 equiv), DMAP (0.15 mmol, 0.075 equiv) and CH₃CN (5 ml). The reaction mixture was stirred at 25 °C open to air until the completion of the reaction, as monitored by TLC. After completion, CH₃CN was evaporated under vacuum. The residue was then diluted with CH₂Cl₂ (5 ml) and filtered through a plug of silica gel to afford the desired product.

References:

Liu, Yangyang;Xie, Aming;Li, Junjian;Xu, Xiao;Dong, Wei;Wang, Boliang [Tetrahedron,2014,vol. 70,# 52,p. 9791 - 9796]

201230-82-2 Synthesis