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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate structure

CAS No.: 680-15-9

Chemical Name:: Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate

Synonyms: METHYL FLUOROSULFONYLDIFLUOROACETATE;METHYL DIFLUORO(FLUOROSULFONYL)ACETATE;METHYL FLUOROSULPHONYLDIFLUOROACETATE;uorosuL;2,2-DifL;FLUOROSULFONYL(DIFLUORO)ACETIC ACID METHYL ESTER;uoro-2-(fL;RSSYY(Iberdomide)-2;Methyldifluor(fluorsulfonyl)acetat;difluoro-2-(fluorosulfonyl)acetate

CBNumber:: CB2685744

Molecular Formula:: C3H3F3O4S

Molecular Weight:: 192.11

MDL Number:: MFCD00144316

MOL File:: 680-15-9.mol

MSDS File:: SDS

Last updated:2025-09-25 17:15:13

Product description	Number	Pack Size	Price
Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97%	390755	5g	$34.2
Methyl Difluoro(fluorosulfonyl)acetate >97.0%(GC)	F0311	5g	$32
Methyl Difluoro(fluorosulfonyl)acetate >97.0%(GC)	F0311	25g	$105
Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate	M301835	1g	$55
Methyl fluorosulfonyldifluoroacetate	006805	5g	$13
More product size

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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Properties

Boiling point	117-118 °C(lit.)
Density	1.509 g/mL at 25 °C(lit.)
refractive index	n20/D 1.351(lit.)
Flash point	118 °F
storage temp.	2-8°C(protect from light)
form	liquid
Specific Gravity	1.52
color	colorless to yellow
BRN	1812896
InChI	InChI=1S/C3H3F3O4S/c1-10-2(7)3(4,5)11(6,8)9/h1H3
InChIKey	GQJCAQADCPTHKN-UHFFFAOYSA-N
SMILES	C(OC)(=O)C(F)(F)S(F)(=O)=O
CAS DataBase Reference	680-15-9(CAS DataBase Reference)
EPA Substance Registry System	Acetic acid, 2,2-difluoro-2-(fluorosulfonyl)-, methyl ester (680-15-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05

Signal word

Danger

Hazard statements

H226-H314

Precautionary statements

P210-P233-P240-P280-P303+P361+P353-P305+P351+P338

Hazard Codes

C,Xi

Risk Statements

10-34

Safety Statements

26-36/37/39-45-16

RIDADR

UN 2920 8/PG 2

WGK Germany

10-21

Hazard Note

Irritant

TSCA

HazardClass

3.2

PackingGroup

III

HS Code

29159000

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
2		1

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	390755	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97%	680-15-9	5g	$34.2	2025-07-31	Buy
TCI Chemical	F0311	Methyl Difluoro(fluorosulfonyl)acetate >97.0%(GC)	680-15-9	5g	$32	2025-07-31	Buy
TCI Chemical	F0311	Methyl Difluoro(fluorosulfonyl)acetate >97.0%(GC)	680-15-9	25g	$105	2025-07-31	Buy
TRC	M301835	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate	680-15-9	1g	$55	2021-12-16	Buy
Oakwood	006805	Methyl fluorosulfonyldifluoroacetate	680-15-9	5g	$13	2021-12-16	Buy

Product number	Packaging	Price	Buy
390755	5g	$34.2	Buy
F0311	5g	$32	Buy
F0311	25g	$105	Buy
M301835	1g	$55	Buy
006805	5g	$13	Buy

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellow liquid

Uses

Efficient reagent for the trifluoromethylation of aryls and difluorocyclopropanation of alkenes.

Uses

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate is a useful reagent for the trifluoromethylation of alkyl halides. It is also broadly applicable reagent for perfluoroalkylations for aryl iodides and bromides.

reaction suitability

reaction type: click chemistry

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate synthesis

Synthesis of Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate from Methanol and 2-(Fluorosulfonyl)difluoroacetylchloride

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

3,4-BIS(TRIFLUOROMETHYL)NITROBENZENE METHYL HEPTAFLUOROBUTYRATE 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE 1-Bromo-4-(2,2,2-trifluoroethyl)benzene

5-bromo-2-(trifluoromethyl)pyrimidine 1-Nitro-4-(2,2,2-trifluoroethyl)benzene 4-Chloro-1-(phenylsulfonyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine

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Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Suppliers

Global( 285)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58
SHANGHAI FLUORORING PHARMACEUTICAL CO LTD	17501600223	sales@fluororing.com	China	76	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8768	58
Springchem New Material Technology Co.,Limited	+86-021-62885108 +8613917661608	info@spring-chem.com	China	2068	57
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13493	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21614	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58

Supplier	Advantage
CD Chemical Group Limited	58
SHANGHAI FLUORORING PHARMACEUTICAL CO LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Springchem New Material Technology Co.,Limited	57
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-27	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 680-15-9	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-29	Methyl 2-(fluorosulfonyl)difluoroacetate 680-15-9	US $890.00 / Kg	0.100Kg	98	5000 Kg	R&D Scientific Inc.
2025-04-04	Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 680-15-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate
680-15-9
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Methyl 2-(fluorosulfonyl)difluoroacetate
680-15-9
US $890.00 / Kg
98
R&D Scientific Inc.

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate
680-15-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Spectrum

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)MS Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)¹HNMR Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)¹³CNMR Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)IR1 Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(680-15-9)Raman

680-15-9(Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate)Related Search:

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METHYL 2-(FLUOROSULFONYL)DIFLUOROACETATE METHYL 2,2-DIFLUORO-2-(FLUOROSULFONYL)ACETATE METHYL 2,2-DIFLUORO-2-(FLUOROSULFONYL)-A FLUOROSULFONYL ACETIC ACID METHYL ESTER Methyl fluorosulphonyldifluoroacetate 97% Methylfluorosulphonyldifluoroacetate97% Difluoro(fluorosulfonyl)acetic acid methyl ester Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate,97% Fluorosulfonyldifluoroacetic Acid Methyl Ester Methyl Difluoro(fluorosulfonyl)acetate Difluoro(fluorosulphonyl)acetic acid methyl ester, 1,1-Difluoro-2-methoxy-2-oxoethane-1-sulphonyl fluoride Methyl difluoro(fluorosulphonyl)acetate 97% Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97% Methyl acetate fluorine sulfonyl 2 fluorine uoro-2-(fL 2,2-Difluoro-2-(fluorosulfonyl)-acetic acid methyl ester MethylDifluoro(fluorosulfonyl)acetate> Acetic acid, 2,2-difluoro-2-(fluorosulfonyl)-, methyl ester Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate ISO 9001：2015 REACH Methyldifluor(fluorsulfonyl)acetat Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 680-15-9 high quality METHYL DIFLUORO(FLUOROSULFONYL)ACETATE METHYL FLUOROSULFONYLDIFLUOROACETATE METHYL FLUOROSULPHONYLDIFLUOROACETATE FLUOROSULFONYL(DIFLUORO)ACETIC ACID METHYL ESTER 2,2-DifL uorosuL difluoro-2-(fluorosulfonyl)acetate Methy 2,2-difluoro-2-(fluorosulfonyl)acetate RSSYY(Iberdomide)-2 ethyl 2,2-difluoro-2-(fluorosulfonyl)acetate Methyl2-fluoro-2-(fluorosulfonyl)acetate Methyl difluoro(fluorosulphonyl)acetate 680-15-9 C3H3F3O4S FSO2CF2CO2CH3 Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Fluorinated Building Blocks Organic Building Blocks Sulfur Compounds Sulfonyl Halides Building Blocks Small molecule Fluorinated Building Blocks Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds Synthetic Organic Chemistry Organic Building Blocks Sulfonyl Halides Sulfur Compounds