2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one synthesis
- Product Name:2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one
- CAS Number:20348-09-8
- Molecular formula:C7H6N2O2
- Molecular Weight:150.13
16867-03-1
79-04-9
20348-09-8
A reaction mixture was prepared by mixing a solution of 2-amino-3-hydroxypyridine (45 mmol) and sodium bicarbonate (51 mmol) in water (30 mL) with 2-butanone (30 mL). A solution of 2-butanone (10 mL) with chloroacetyl chloride (51 mmol) was slowly added dropwise under ice-bath cooling conditions, and the rate of dropwise acceleration was controlled to keep the reaction temperature from exceeding 10°C. The reaction was carried out at room temperature. After dropwise addition, stirring was continued at room temperature for 30 min, and then the reaction was warmed up to 75°C for 1 hr. Upon completion of the reaction, the reaction solution was concentrated and purified by recrystallization (methanol/water=1:1) to afford 4.3 g of the target product 2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one.
16867-03-1
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$10.00/25g
79-04-9
382 suppliers
$12.00/5g
20348-09-8
130 suppliers
$6.00/250mg
![Acetonitrile, 2-[(2-nitro-3-pyridinyl)oxy]-](/CAS/20200611/GIF/1268818-15-0.gif)
1268818-15-0
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20348-09-8
130 suppliers
$6.00/250mg
16867-03-1
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79-11-8
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$24.00/25g
20348-09-8
130 suppliers
$6.00/250mg
16867-03-1
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105-36-2
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$5.00/5 g
20348-09-8
130 suppliers
$6.00/250mg