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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2-Amino-3-hydroxypyridine
16867-03-1

2-Amino-3-hydroxypyridine synthesis

10synthesis methods
2-Amino-3-hydroxypyridine was used as reagent in reaction of dimethyl acetylenedicarboxylate and triphenylphosphine to yield functionalized coumarins and 1,4-oxazines.  It was prepared from 2-hydroxy-3-nitropyridine with 10% Pd/C by stirring in methanol for overnight at room temperature.
6332-56-5 Synthesis
3-Nitro-2-pyridinol

6332-56-5
355 suppliers
$10.00/5g

2-Amino-3-hydroxypyridine

16867-03-1
586 suppliers
$10.00/25g

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Yield:16867-03-1 89%

Reaction Conditions:

palladium-carbon in methanol

Steps:

1 a)Preparation of 2-amino-3-hydroxypyridine
a)Preparation of 2-amino-3-hydroxypyridine To a solution of 2-hydroxy-3-nitropyridine (5 g, 45.4 mmol) in methanol(250 ml) was added 10% Pd/C (1 g). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 min. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (5% MeOH/CH2Cl2) gave the desired product(3.2 g, 89%). 1H NMR (CD3OD): δ 6.96 (d, 1H), 6.90 (dd, 1H), 6.77 (d, 1H).

References:

SmithKline Beecham Corporation US6218539, 2001, B1

FullText

15128-82-2 Synthesis
3-Hydroxy-2-nitropyridine

15128-82-2
463 suppliers
$10.00/10g

2-Amino-3-hydroxypyridine

16867-03-1
586 suppliers
$10.00/25g

References
680-31-9 Synthesis
Hexamethylphosphoramide

680-31-9
475 suppliers
$13.00/25g

611-13-2 Synthesis
Methyl 2-furoate

611-13-2
437 suppliers
$13.00/25g

2-Amino-3-hydroxypyridine

16867-03-1
586 suppliers
$10.00/25g

References
680-31-9 Synthesis
Hexamethylphosphoramide

680-31-9
475 suppliers
$13.00/25g

2-FURAMIDE

609-38-1
107 suppliers
$19.00/1g

2-Amino-3-hydroxypyridine

16867-03-1
586 suppliers
$10.00/25g

References
874-24-8 Synthesis
3-Hydroxypicolinic acid

874-24-8
301 suppliers
$14.14/1gm:

2-Amino-3-hydroxypyridine

16867-03-1
586 suppliers
$10.00/25g

References

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