3-(1-Pyridinio)-1-propanesulfonate synthesis
- Product Name:3-(1-Pyridinio)-1-propanesulfonate
- CAS Number:15471-17-7
- Molecular formula:C8H11NO3S
- Molecular Weight:201.24
110-86-1
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1120-71-4
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15471-17-7
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$13.00/5g
Yield:15471-17-7 86%
Reaction Conditions:
in ethyl acetate at 60; for 2.5 h;
Steps:
16.1
(1) in the equipped with a stirrer,thermometer,Calcium chloride drying tube and dropping funnelNecked flask was charged with 6.10 g (0.05 mol)1,3-propanesultone and150 mL of ethyl acetate was added and stirred until 1,3-propanesultone was dissolved,The flask was heated to 60 ° C in an oil bath equipped with methyl silicone oil,A solution of 5.14 g (0.065 mol) of pyridine was slowly added dropwise50 mL of ethyl acetate,After the completion of the dropwise addition (dropwise time: 30 min)Insulation reaction 2h,Pressure filtration,The residue was washed with ethyl acetate,Vacuum drying,To give N- (3-sulfonic acid) propylpyridine as an internal salt (Py-PS) 8.64 g,The yield was 86.0%.
References:
CN104926664,2016,B Location in patent:Paragraph 0119
