3-(4-Chlorophenyl)-9-phenyl-9H-carbazole synthesis
- Product Name: 3-(4-Chlorophenyl)-9-phenyl-9H-carbazole
- CAS Number:1026033-57-7
- Molecular formula:C24H16ClN
- Molecular Weight:353.8435
854952-58-2
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106-39-8
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Yield:1026033-57-7 97%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in tetrahydrofuran;water at 80; for 8 h;Inert atmosphere;Reflux;
Steps:
1.1 Synthesis Example 1: Synthesis of intermediate I-1
In nitrogen 9-phenyl-9H-carbazol-3-ylboronic acid (100 g, 348 mmol) of tetrahydrofuran (THF) 0. 9 L senses a rotation velocity of the disk to, herein 1-bromo-4-chlorobenzene (73. 3 g, 383 mmol) and tetrakis (triphenylphosphine) palladium (4. 02 g, 3. 48 mmol) visitor is checked through a and agitating an alcohol is put into a container. Potassuim carbonate saturated in water (128 g, 870 mmol) in 80 °C doesn't have any error frames, the reflux by heating at a 8. Complete after reaction solution at a water doesn't have any error frames, then dichloromethane (DCM) extraction of water to the MgSO4 anhydride after triggers number, filter and was, concentrating it under reduced pressure. Thus-obtained residue number intermediate that is forward separated into flash column chromatography I-1 (119 g, 97%) is obtained
References:
KR2016/91198,2016,A Location in patent:Paragraph 0191
1153-85-1
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