ChemicalBook CAS DataBase List 3,4-Dibenzyloxybenzaldehyde

3,4-Dibenzyloxybenzaldehyde synthesis

12synthesis methods

Product Name:3,4-Dibenzyloxybenzaldehyde
CAS Number:5447-02-9
Molecular formula:C21H18O3
Molecular Weight:318.37

100-44-7 Synthesis

100-44-7
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$13.50/250G

139-85-5
797 suppliers
$5.00/1g

5447-02-9
234 suppliers
$6.00/5g

Yield:5447-02-9 96%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20 - 130; for 4 h;

Steps:

1.1 (1) Synthesis of 3,4-dibenzyloxybenzaldehyde:
55.2 g (0.40 mol) of protocatechualdehyde was dissolved in 600 mLN, N-dimethylformamide,116.0 g (0.92 mol) of benzyl chloride was slowly added,Anhydrous K2CO3165.6 g (1.2 mol) was weighed and added thereto,The reaction was stirred at room temperature for 2 hours,Further, 35.2 g (0.40 mol) of K2CO3,130 heated for 2 hours,Cooled to room temperature,Filtration,The filtrate was added to ice water,Acidified with dilute hydrochloric acid,Yielding a yellow precipitate,Filtration,Washed with ice water,Yielding 122.1 g of 3,4-dibenzyloxybenzaldehyde in 96% yield.

References:

Northwestern University;Xi'an Shiyou University;Zheng, Xiaohui;Bai, Yajun;Zhang, Qunzheng;Nan, Yefei;Qin, Fanggang;Liu, Pei;Fang, Jiacheng CN104030923, 2016, B Location in patent:Paragraph 0030; 0058; 0059; 0060

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