3,4-DICHLOROPICOLINAMIDE synthesis
- Product Name:3,4-DICHLOROPICOLINAMIDE
- CAS Number:1025720-99-3
- Molecular formula:C6H4Cl2N2O
- Molecular Weight:191.01
1346167-25-6
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1025720-99-3
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Yield:1025720-99-3 97%
Reaction Conditions:
with Acetaldehyde oxime;copper(II) oxide in water; for 2 h;Reflux;
Steps:
Experimental Procedures for Hydration of Various Nitriles
General procedure: To a 25 mL round-bottom flask equipped with magnetic stirrer were added nitrile (2.5 mmol), acetaldoxime (3.75 mmol), copper oxide (0.25 mmol) and H2O (10 mL). The mixture was heated to reflux for 2-14 h. After cooling to room temperature, the solution was directly evaporated to dryness and the residue was purified by column chromatography on silica gel (ethyl acetate/n-hexane) to give the corresponding amides. The commercially available amides were characterised by melting points, 2-amino-5-bromobenzamide (Table 2, entry 6) and 3,4-dichloropicolinamide (Table 2, entry 13) were characterised by NMR spectra and LC-MS.
References:
Ma, Xiao-Yun;He, Ying;Hu, Yu-Lin;Lu, Ming [Tetrahedron Letters,2012,vol. 53,# 4,p. 449 - 452] Location in patent:supporting information; experimental part
55934-00-4
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1025720-99-3
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959578-03-1
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1025720-99-3
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24424-99-5
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959578-03-1
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1025720-99-3
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55934-00-4
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1025720-99-3
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