ChemicalBook CAS DataBase List Hydroxytyrosol

Hydroxytyrosol synthesis

13synthesis methods

Product Name:Hydroxytyrosol
CAS Number:10597-60-1
Molecular formula:C8H10O3
Molecular Weight:154.16

3,4-DIHYDROXYPHENYLACETIC ACID METHYL ESTER

25379-88-8
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$38.00/1g

10597-60-1
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$28.00/100mg

Yield:10597-60-1 99%

Reaction Conditions:

with sodium tetrahydridoborate at 20; for 2.5 h;Cooling with ice;Reagent/catalyst;

Steps:

1-4; 2-4 1-4 Synthesis of Hydroxytyrosol

Into a 100 mL three-necked flask, add ice-water mixture, 5.2 g of sodium borohydride, and 6.9 g of methyl 3,4-dihydroxyphenylacetate in turn while stirring, and slowly return to room temperature for 2.5 hours. After the spotting reaction is completed, add 2NHCl was adjusted to PH2-3, a lot of bubbles were generated, an appropriate amount of ethyl acetate was added, the aqueous phase was extracted twice with ethyl acetate, the organic phases were combined, and evaporated to dryness under reduced pressure to obtain 5.8g of light yellow oil, that is, hydroxytyrosol, yield 99%.

References:

CN114195640,2022,A Location in patent:Paragraph 0057; 0072-0076; 0078; 0085-0086

96826-11-8 Synthesis