3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one synthesis
- Product Name:3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one
- CAS Number:4224-87-7
- Molecular formula:C16H14O
- Molecular Weight:222.28
100-52-7
971 suppliers
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122-00-9
712 suppliers
$5.00/25g
4224-87-7
15 suppliers
$28.60/10mg
Yield:4224-87-7 95%
Reaction Conditions:
with sulfuric acid in 1,4-dioxane at 90; for 2 h;Inert atmosphere;
Steps:
1 Example 1: A synthesis method of chalcone derivatives:
Add 5 mmol of polyphosphoric acid PPA (analytical grade) to the round bottom flaskAnd solvent 1,4-dioxane (analytical grade) 2mL,Then add 98% concentrated sulfuric acid 20mmol,Benzaldehyde 0.7mmol,P-methyl(p-CH3)acetophenone 1mmol,Under the protection of nitrogen, heating and stirring in an oil bath at 90 for 2hAfter the reaction, it was extracted 3 times with 50ml ethyl acetate.Take the organic layer,Use tap water,Wash with saturated sodium chloride solution,After drying and washing the organic layer with anhydrous sodium sulfate,filter;The resulting filtrate was concentrated under reduced pressure,The concentrated residue is then used for silica gel column chromatography(Petroleum ether: ethyl acetate volume ratio is 50:1) separation and purification,The chalcone derivative I-1 is obtained; the yield is 95%.
References:
CN111285759,2020,A Location in patent:Paragraph 0045-0047; 0081; 0082; 0088
589-18-4
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98-86-2
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4224-87-7
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$28.60/10mg
1669-50-7
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