ChemicalBook CAS DataBase List 3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one

3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one synthesis

10synthesis methods

Product Name:3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one
CAS Number:4224-87-7
Molecular formula:C16H14O
Molecular Weight:222.28

100-52-7 Synthesis

100-52-7
951 suppliers
$20.37/250g

122-00-9 Synthesis

122-00-9
668 suppliers
$5.00/25g

3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one

4224-87-7
13 suppliers
$28.60/10mg

Yield:4224-87-7 95%

Reaction Conditions:

with sulfuric acid in 1,4-dioxane at 90; for 2 h;Inert atmosphere;

Steps:

1 Example 1: A synthesis method of chalcone derivatives:

Add 5 mmol of polyphosphoric acid PPA (analytical grade) to the round bottom flaskAnd solvent 1,4-dioxane (analytical grade) 2mL,Then add 98% concentrated sulfuric acid 20mmol,Benzaldehyde 0.7mmol,P-methyl(p-CH3)acetophenone 1mmol,Under the protection of nitrogen, heating and stirring in an oil bath at 90 for 2hAfter the reaction, it was extracted 3 times with 50ml ethyl acetate.Take the organic layer,Use tap water,Wash with saturated sodium chloride solution,After drying and washing the organic layer with anhydrous sodium sulfate,filter;The resulting filtrate was concentrated under reduced pressure,The concentrated residue is then used for silica gel column chromatography(Petroleum ether: ethyl acetate volume ratio is 50:1) separation and purification,The chalcone derivative I-1 is obtained; the yield is 95%.

References:

CN111285759,2020,A Location in patent:Paragraph 0045-0047; 0081; 0082; 0088

589-18-4 Synthesis